[Frontiers in Bioscience 2, d12-26, January 1, 1997]
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CYTOKINES IN ACUTE AND CHRONIC INFLAMMATION

Carol A. Feghali, Ph.D., and Timothy M. Wright, M.D.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, E1109 Biomedical Science Tower, 200 Lothrop St., Pittsburgh, PA 15261

Received 11/06/96; Accepted 12/13/96; On-line 01/01/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1 Cytokines involved in acute inflammation
3.1.1 Interleukin-1
3.1.2 Tumor necrosis factor
3.1.3 Interleukin-6
3.1.4 Interleukin-11
3.1.5 Interleukin-8/chemokines
3.1.6 Eotaxin
3.1.7 Interleukin-16
3.1.8 Interleukin-17
3.1.9 Colony stimulating factors
4.1 Cytokines involved in chronic inflammation
4.1.1 The humoral inflammatory response
4.1.1.1 Interleukin-3
4.1.1.2 Interleukin-4
4.1.1.3 Interleukin-5
4.1.1.4 Interleukin-7
4.1.1.5 Interleukin-9
4.1.1.6 Interleukin-10
4.1.1.7 Interleukin-13
4.1.1.8 Interleukin-14
4.1.1.9 Transforming growth factor-ß
4.1.2 The cellular inflammatory response
4.1.2.1 Interleukin-2
4.1.2.2 Interleukin-12
4.1.2.3 Interleukin-15
4.1.2.4 Interferons
4.1.2.5 IFN-gamma-inducing factor
5.1 Receptors of inflammatory cytokines
6. Summary
7. References
8. Entire manuscript

Key words: Inflammation, Cytokines, Interleukins