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PROSTAGLANDINS AND CANCER
Susan M. Fischer
The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957
Received 9/3/97 Accepted 9/23/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3.The Arachidonate Cascade
- 3.1Metabolic Pathways
- 3.2Regulation of Metabolism
- 3.2.1 Phospholipase A2
- 3.2.2 Prostaglandin synthases/Cyclooxygenases
- 3.2.3 Lipoxygenases
3.3 Receptors
4. Human Cancer and Experimental Animal Models
4.1 Skin Carcinogenesis
4.2 Tumors of the Colon
4.3 Tumors of the Breast
5. Mechanisms of Prostaglandin Action
5.1 Cell proliferation
5.2 Role in Apoptosis
5.3 Carcinogen Metabolism
5.4 Immune Modulation
6 Summary
7. Acknowledgments
8. References
9. Entire manuscript
Key words: Key words: arachidonic acid, prostaglandins, cancer, colon, skin, nonstroidal anti-inflammatory agents, chemoprevention
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