[Frontiers in Bioscience 2, d353-379, July 15, 1997]
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APOPTOSIS IN TUMORIGENESIS AND CANCER THERAPY

Gaèl McGill and David E. Fisher

Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital, Harvard Medical School, 44 Binney St., Boston, MA 02115

Received 6/15/97 Accepted 6/28/97

TABLE OF CONTENTS


1. Abstract

2. Introduction
3. The biochemistry of apoptosis
3.1 The executioner and its substrates
3.2 Channeling our attention on the Bcl-2 family
3.3 The Fas way to apoptosis
3.4 The PI3-K/Akt survival pathway
4. Apoptosis and cancer
4.1 Apoptosis and tumorigenesis
4.2 Anoikis and anchorage-independence: implications for tumor metastasis
4.3 Hypoxia and angiogenesis
4.4 Antineoplastic therapies
5. Conclusions
6. Acknowledgments
7. References
8. Entire manuscript
Keywords: Apotosis, Fas, Bcl-2, Tumorigenesis, Metastasis, Hypoxia, Angiogenesis

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