[Frontiers in Bioscience 2, d353-379, July 15, 1997]

	[Frontiers in Bioscience 2, d353-379, July 15, 1997] Reprints PubMed CAVEAT LECTOR
	APOPTOSIS IN TUMORIGENESIS AND CANCER THERAPY Gaèl McGill and David E. Fisher Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital, Harvard Medical School, 44 Binney St., Boston, MA 02115 Received 6/15/97 Accepted 6/28/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. The biochemistry of apoptosis 3.1 The executioner and its substrates 3.2 Channeling our attention on the Bcl-2 family 3.3 The Fas way to apoptosis 3.4 The PI3-K/Akt survival pathway 4. Apoptosis and cancer 4.1 Apoptosis and tumorigenesis 4.2 Anoikis and anchorage-independence: implications for tumor metastasis 4.3 Hypoxia and angiogenesis 4.4 Antineoplastic therapies 5. Conclusions 6. Acknowledgments 7. References 8. Entire manuscript Keywords: Apotosis, Fas, Bcl-2, Tumorigenesis, Metastasis, Hypoxia, Angiogenesis Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d353-379, July 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

APOPTOSIS IN TUMORIGENESIS AND CANCER THERAPY
Gaèl McGill and David E. Fisher
Division of Pediatric Hematology/Oncology, Dana Farber Cancer Institute and Children's Hospital, Harvard Medical School, 44 Binney St., Boston, MA 02115

Received 6/15/97 Accepted 6/28/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. The biochemistry of apoptosis: 3.1 The executioner and its substrates; 3.2 Channeling our attention on the Bcl-2 family; 3.3 The Fas way to apoptosis; 3.4 The PI3-K/Akt survival pathway
4. Apoptosis and cancer: 4.1 Apoptosis and tumorigenesis; 4.2 Anoikis and anchorage-independence: implications for tumor metastasis; 4.3 Hypoxia and angiogenesis; 4.4 Antineoplastic therapies
5. Conclusions
6. Acknowledgments
7. References
8. Entire manuscript

Keywords: Apotosis, Fas, Bcl-2, Tumorigenesis, Metastasis, Hypoxia, Angiogenesis

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.