[Frontiers in Bioscience 2, d619-634, December 15, 1997]

	[Frontiers in Bioscience 2, d619-634, December 15, 1997] Reprints PubMed CAVEAT LECTOR
	HUMAN IMMUNODEFICIENCY VIRUS TYPE I AS A TARGET FOR GENE THERAPY Magnús Gottfredsson and Paul R. Bohjanen Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710 Received 11/17/97 Accepted 11/24/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. HIV-1 life cycle 4. Viral targets for gene therapy 4.1. Tat and TAR 4.2. Rev and RRE 4.3. Nef 4.4. The pol gene 4.4.1. Reverse transcriptase 4.4.2. Integrase 4.4.3. Protease 4.5. The gag gene 4.6. The env gene 4.7. Vpr 4.8. The 5' leader sequence 4.9. Packaging sequence y 4.10. HIV-regulated suicide genes 5. Combinations of antiviral strategies 5.1. Ribozymes and RNA decoys 5.2. Trans-dominant mutant combinations 5.3. Multitarget ribozymes 5.4. Other combinations 6. Perspective 7. Acknowledgments 8. References 9. Entire manuscript Key words: HIV-1, AIDS, Gene therapy, Tat, TAR, Rev, PRE, Nef, Vpr, Reverse transcriptase, Integrase, Protease, RNA decoys, Ribozymes, Trans-dominant mutants Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d619-634, December 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

HUMAN IMMUNODEFICIENCY VIRUS TYPE I AS A TARGET FOR GENE THERAPY

Magnús Gottfredsson and Paul R. Bohjanen

Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC 27710

Received 11/17/97 Accepted 11/24/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. HIV-1 life cycle
4. Viral targets for gene therapy: 4.1. Tat and TAR
4.2. Rev and RRE
4.3. Nef
4.4. The pol gene
4.4.1. Reverse transcriptase
4.4.2. Integrase
4.4.3. Protease
4.5. The gag gene
4.6. The env gene
4.7. Vpr
4.8. The 5' leader sequence
4.9. Packaging sequence y
4.10. HIV-regulated suicide genes
5. Combinations of antiviral strategies: 5.1. Ribozymes and RNA decoys
5.2. Trans-dominant mutant combinations
5.3. Multitarget ribozymes
5.4. Other combinations
6. Perspective
7. Acknowledgments
8. References
9. Entire manuscript

Key words: HIV-1, AIDS, Gene therapy, Tat, TAR, Rev, PRE, Nef, Vpr, Reverse transcriptase, Integrase, Protease, RNA decoys, Ribozymes, Trans-dominant mutants

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.