[Frontiers in Bioscience 2, d232-241, June 1, 1997]
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MODULATION OF ARA-C INDUCED APOPTOSIS IN LEUKAMAIA BY THE PKC ACTIVATOR BRYOSTATIN 1

Steven Grant

Division of hermatology , Department of Pharmacology and Microbiology , Medical College of Virginia

Received 5/23/97; Accepted 5/28/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. ara-C
4. Bryostatin 1
5. Bryostatin 1/ara-C interactions
5.1 Biochemical interactions
5.2 Signalling interactions
5.3 Differentiation and apoptosis
5.4 Sequence-dependent interactions
5.5 Role of c-Myc
5.6 Involvement of Bcl-2
6. Future directions
7. Perspectives
8. Acknowledgements
9. References
10. Entire Manuscript

Keywords: apoptosis, ara-c, bryostatin 1, leukamia, PKC

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