INHIBITION OF THE HIV REV TRANSACTIVATOR: A NEW TARGET FOR THERAPEUTIC INTERVENTION
Adriana Heguy
Oncogene Science, Inc., 106 Charles Lindbergh Blvd., Uniondale, NY 11553
Received 6/2/97; Accepted 6/4/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
3. Rev structure and function
- 3.1 Rev domains
- 3.2 Rev-RRE interactions
- 3.3 Cellular factors that interact with Rev
- 3.4 Mechanism of action of Rev
- 4. Rev as target for therapeutic intervention
- 4.1 Rev as a target for gene therapy
- 4.1.1 Protein-based suppressors of Rev function
- 4.1.2 Intracellular expression of RNA-based Rev inhibitors
- 4.2 Inhibiting Rev function via antisense oligonucleotides and other nucleic-acid molecules
- 4.3 Low-molecular weight compounds and natural products that inhibit Rev
- 4.3.1 Intercalating agents and other RNA-binding compounds
- 4.3.2 Screening approaches
- 5. Conclusions and Perspective
- 6. Acknowledgments
- 7. References
- 8. Entire manuscript
Keywords:HIV, AIDS, Therapy, Immune System, Rev transactivator
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