[Frontiers in Bioscience 2, d61-77, February 15, 1997]

	[Frontiers in Bioscience 2, d61-77, February 15, 1997] Reprints PubMed CAVEAT LECTOR
	ANTIGEN-INDUCED DEATH OF T-LYMPHOCYTES Dieter Kabelitz & Ottmar Janssen Department of Immunology, Paul-Ehrlich-Institute, Langen, Germany Received 1/24/97; Accepted 1/31/97 On-line 2/15/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 2.1 Features of apoptosis 2.2 Role of death molecules 2.3 Apoptosis in intrahymic T-cell development 3. Activation-induced cell death (AICD) of mature T-Lymphocytes 3.1 Induction via the CD3/T-cell receptor molecular complex 3.2 AICD triggered by superantigens 3.3 AICD triggered by conventional antigens 3.4 Role of Fas/Fas-Ligand interaction in antigen-induced AICD 4. Clinical implications 4.1 Role of AICD in peripheral T-cell tolerance 4.2 Therapeutical perspectives in autoimmune diseases 5. Concluding remarks 6. References 7. Entire manuscript Key words: Antigen, Apoptosis, Autoimmune Disease, Immunology, Peripheral Tolerance, Programmed Cell Death, T-Lymphocytes, 47 Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d61-77, February 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

ANTIGEN-INDUCED DEATH OF T-LYMPHOCYTES

Dieter Kabelitz & Ottmar Janssen

Department of Immunology, Paul-Ehrlich-Institute, Langen, Germany

Received 1/24/97; Accepted 1/31/97 On-line 2/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction: 2.1 Features of apoptosis; 2.2 Role of death molecules; 2.3 Apoptosis in intrahymic T-cell development
3. Activation-induced cell death (AICD) of mature T-Lymphocytes: 3.1 Induction via the CD3/T-cell receptor molecular complex; 3.2 AICD triggered by superantigens; 3.3 AICD triggered by conventional antigens; 3.4 Role of Fas/Fas-Ligand interaction in antigen-induced AICD
4. Clinical implications: 4.1 Role of AICD in peripheral T-cell tolerance; 4.2 Therapeutical perspectives in autoimmune diseases
5. Concluding remarks
6. References
7. Entire manuscript

Key words: Antigen, Apoptosis, Autoimmune Disease, Immunology, Peripheral Tolerance, Programmed Cell Death, T-Lymphocytes, 47

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.