[Frontiers in Bioscience 2, d207-221, May 1, 1997]
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RECENT ADVANCES IN LYMPHOCYTE SIGNALING AND REGULATION

Chun Kung and Matthew L. Thomas

Department of Pathology, HHMI, Washington University, 660 S. Euclid Avenue, St. Louis, MO 63110

Received 4/4/97; Accepted 4/24/97; On-line 5/1/97

TABLE OF CONTENTS

1. Abstract
2. Introduction: current model for antigen receptor signaling in lymphocytes
3. Protein tyrosine kinases
3.1 Signaling pathways involving protein tyrosine kinases
3.2 Regulation of protein tyrosine kinase activity
3.3 Lymphocyte development
4. The protein tyrosine phosphatase, CD45
4.1 CD45 regulates protein tyrosine kinases
4.2 The extracellular domain of CD45 affects antigen-mediated signal transduction
4.3 Effects of CD45 in lymphocyte development
4.4 Regulation of CD45 activity
4.5 CD45 is involved in cell adhesion
5. Acknowledgements
6. References
7. Entire manuscript

Keywords: lymphocytes, signaling, regulation, TCR, BCR, Lck, CD45