[Frontiers in Bioscience 2, d606-618, December 15, 1997]
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CAVEAT LECTOR




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HIV-1 Nef AND HOST CELL PROTEIN KINASES

Kalle Saksela

Institute of Medical Technology, University of Tampere, P.O. Box 607, FIN-33101, Tampere, Finland

Received 11/10/97 Accepted 11/17/97

TABLE OF CONTENTS

1. Abstract
2. Phenotypic effects of Nef expression
3. Cellular partners and targets of Nef
3.1. Nef associated tyrosine kinases
3.1.1. Introduction into the Src family of tyrosine kinases
3.1.2. SH3 / Nef interaction
3.1.3. Role of the PxxP motif in vivo
3.1.4. Hck and Lyn
3.1.5. Lck and other SH3 proteins
3.2. Nef associated serine kinases
3.2.1. Nef-associated 62/72 kD kinase (NAK)
3.2.2. Other serine kinases associated with Nef
3.3. How similar are HIV and SIV Nef?

4. Concluding remarks
5. References
6. Entire manuscript

Key words: Nef, HIV, SIV, AIDS, protein kinase, signal transduction, SH3 domain