![]()
|
[Frontiers in Bioscience 2, d519-526-379, November 1, 1997] Reprints PubMed CAVEAT LECTOR |
|
|---|---|---|
![]() ![]() ![]()
|
ROLE OF MMTV INTEGRATION LOCUS CELLULAR GENES IN BREAST CANCER Rajeshwar Rao Tekmal, and Nagalakshmi Keshava Department of Gynecology and Obstetrics and Winship Cancer Center, Emory University School of Medicine, Atlanta, GA 30322-4710, USA Received 10/14/97 Accepted 10/17/97 9. REFERENCES: 1. American Cancer Society. Cancer facts and figures, pp. 11-13, 1996. 2. R. Callahan: MMTV-induced mutations in mouse mammary tumors: Their potential relevance to human breast cancer. Breast Cancer Research and Treatment 39, 33-44 (1996) 3. J. Jonkers, A. Berns: Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim Biophys Acta 1287, 29-57 (1996) 4. R. Weiss, N. Teich, H. Varmus et al. Molecular biology of tumor viruses. Cold Spring Harbor Laboratory, Cold Spring Harbor NY, pp.l6-18, 1982. 5. A. Marchetti, J. Robbins, G. Campbell. Host genetic background effect on the frequency of mouse mammary tumor virus-induced rearrangements of int-l and int-2 loci in mouse mammary tumors. J Virol 65, 4550-4554 (1991) 6. D. Medina: Preneoplastic lesions in mouse mammary tumorigenesis. Method Cancer Res 7, 3-53 (1973) 7. K.B. DeOme, L.J. Faulkin, H.A. Bern: Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H mice. J Natl Cancer Inst 78, 751-757 (1959) 8. C. Daniel, K. DeOme, L. Young: The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. Proc Natl Acad Sci USA 61, 53-60 (1968) 9. R. Nusse: The activation of cellular oncogenes by proviral insertion in murine mammary cancer. In: Lippman ME, Dickson RB (eds) Breast Cancer: Cellular and Molecular Biology. Kluwer Academic Publishers, Norwell MA, pp 283-306 (1988) 10. C. Dickson, V. Fantl: Fgf-3, an oncogene in murine breast cancer. In: Lippman ME, Dickson RB (eds) Mammary tumorigenesis and malignant progression. Kluwer Academic Publishers, Norwell MA, pp. 331-344 (1994) 11.J. Robbins, B.J. Blondel, D. Gallahan, R. Callahan: Mouse mammary tumor gene int-3: A member of the notch gene family transforms mammary epithelial cells. J Virol 66, 2594-2599 (1992) 12. C. Jhappan, D. Gallahan, C. Stahle, E. Chu, G.H. Smith, G. Merlino, R. Callahan: Expression of an activated notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6, 345-355 (1992) 13. D.A.Gray, C.M. McGrath, R.F. Jones, V.L. Morris: A common mouse mammary tumor virus integrations site in chemically induced precancerous mammary hyperplasias. Virology 30, 360-368, 1986. 14.V.L. Morris, T.R. Rao, C.A. Kozak, D.A. Gray, E.C. Lee Chan, T.J. Cornell, C.B. Taylor, R.F. Jones, C.M. McGrath: Characterization of int-5, a locus associated with early events in mammary carcinogenesis. Oncogene Res 6, 53-63 (1991) 15. A. Marchetti, F. Buttitta, S. Miyazaki, D. Gallahan, G.H. Smith, R.J. Callahan: Int-6, a highly conserved, widely expressed gene, is mutated by mouse mammary tumor virus in mammary preneoplasia. Virol 69, 1932-1938 (1995) 16. C. Dickson, R. Smith, S. Brookes, G. Peters: Tumorigenesis by mouse mammary tumor virus: proviral activation of a cellular gene in the common integration region int-2. Cell 37, 529-536 (1984) 17. R. Nusse, H.E. Varmus. Many tumors induced by the mouse mammary tumors virus contain a provirus integrated in the same region of the host genome. Cell 31, 99-109 (1982) 18. G. Peters, S. Brookes, R. Smith, M. Placzek, C. Dickson: The mouse homolog of the hst/K-FGF gene is adjacent to int-2 and activated by proviral insertion in some virally induced mammary tumors. Proc Natl Acad Sci USA 86, 5678-5682 (1989) 19. C.A. MacArthur, D.B. Shankar, G.M. Schackleford. Fgf-8, activated by proviral insertion, cooperates with the Wnt-l transgene in murine mammary tumorigenesis. J Virol 69, 2501-2507 (1995) 20.H. Roelink, E. Wagenaar, S. Lopes da Silva, R. Nusse: Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-l/Wnt-l and is normally expressed in mouse embryos and adult brain. Proc Natl Acad Sci USA 87, 4519-4523 (1990) 21.C.Dickson, R. Smith, S. Brookes, G. Peters: Proviral insertions within the int-2 gene can generate multiple anomalous transcripts but leave the protein-coding domain intact. J Virol 64, 784-93 (1990) 22.H. Roelink, E. Wagenaar & R. Nusse. Amplification and proviral activation of several Wnt genes during progression and clonal variation of mouse mammary tumors. Oncogene 7, 487-492 (1992) 23.F.V. Leeuwen & R. Nusse.Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer. Seminars Cancer Biol 6, 127-133 (1995) 24.C. Jhappan, D. Gallahan, C. Stahle, E. Chu, G.H. Smith: Expression of an activated notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev 6, 345-355 (1992) 25.C. Desbois, R. Rousset, F. Bantignies, P. Jalinot: Exclusion of Int-6 from PML nuclear bodies by binding to the HTLV-l Tax oncoprotein. Science 273, 951-53 (1996) 26.D.A. Gray, C.M. McGrath, R.F. Jones, V.L. Morris: A common mouse mammary tumor virus integration site in chemically induced precancerous mammary hyperplasias. Virology 30, 360-368 (1986) 27.R.L. Ashley, R.D. Cardiff & T.G. Fanning: Re-evaluation of the effect of mouse mammary tumor virus infection on the BALB/c mouse hyperplastic outgrowth. J Natl Cancer Inst 65, 977-986 (1980) 28.B.L. Slagle, D.A. Wheeler, G.L. Hager, D. Medina, J.S. Butel: Molecular basis of altered mouse mammary tumor virus expression in the D-2 hyperplastic alveolar nodule line of BALB/c mice. Virology 143, 1-15 (1985) 29.V.R. Durgam & R.R. Tekmal: The nature and expression of int-5, a novel MMTV integration locus gene in carcinogen-induced mammary tumors. Cancer Lett 87, 179-86 (1994) 30.R.R. Tekmal & V.R. Durgam: The overexpression of int-5/aromatase, a novel MMTV integration locus gene, is responsible for D2 mammary tumor cell proliferation. Cancer Lett 88, 147-155 (1995) 31.V.R. Durgam, J.A. Easton, R. Surya, R.R. Tekmal: Structure of the int-5, a novel MMTV integration genomic locus containing mouse early transposon LTR homolog region. Biochimica et Biophysica Acta 1263, 89-92 (1995) 32.A.M.H. Brodie & R.J. Santen: Aromatase and its inhibitors in breast cancer: overview and perspective. Breast Cancer Res Treat 30, 1-6 (1994) 33.T.R. Evans, M.G. Rowlands, M.C. Silva, M. Lae, R.C. Coombes: Prognostic significance of aromatase and estrone sulfatase enzymes in human breast cancer. J Steroid Biochem Mol Biol 44, 583-587 (1993) 34.M.J. Reed: The role of aromatase in breast tumors. Breast Cancer Res Treat 30, 7-17 (1994) 35.A.S. Tsukamoto, R. Grosschedl, R.C. Guzman, T. Parslow, H.E. Varmus: Expression of the int-l gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 55, 619-625 (1988) 36.R. Nusse, A. VanOoyen, D. Cox, Y.K. Fung, H. Varmus: Mode of proviral activation of a putative mammary oncogene (int-l) on mouse chromosome 15. Nature 307, 131-136 (1984) 37.H. Kwan, V. Pecenka, A. Tsukamoto, T.G. Parslow, R. Guzman, T.P. Lin, W.J. Muller, F.S. Lee: Transgenes expressing the Wnt-l and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol 12, 147-154 (1992) 38.G. Stamp, V. Fantl, R. Poulsom, S. Jamieson, R. Smith, G. Peters, Dickson: Non-uniform expression of a mouse mammary tumor virus-driven int-2/fgf-3 transgene in pregnancy-responsive breast tumors. Cell Growth Differ 3, 929-938 (1992) 39.D. Gallahan & R. Callahan: Mammary tumorigenesis in feral mice: Identification of a new int locus in mouse mammary tumor virus (czech II) induced mammary tumors. J Virol 61, 66-74 (1987) 40.R.R. Tekmal, N. Ramachandra, S. Gubba, V.R. Durgam, J. Mantione, K. Toda: Overexpression of int-5/aromatase in mammary glands of transgenic mice results in the induction of hyperplasia and nuclear abnormalities. Cancer Res 56, 3180-3185 (1996) 41.D. Gallahan, C. Escot, E. Hogg et al. Mammary tumorigenesis in feral species of the genus Mus. In: Potter M (ed) The Wild Mouse in Immunology [Current Topics in Microbiology and Immunology]. Springer Verlag, Heidelbeg, 1986 42.B.R. Cullen, P.T. Lomedico, G. Ju: Transcriptional interference in avian retroviruses-implications for the promoter insertion model of leukemogenesis. Nature 307, 241-245 (1984) 43. R. Mesa-Tejada, I. Keydar, M. Ramanarayanan, T. Ohno, C. Fenoglio, S. Spiegelman: Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus. Proc Natl Aca Sci 75, 1529-1533 (1978) 44. P. Levine, N. Mourali, F. Tabbave, J. Costa, R. Mesa-Tejada, S. Spiegelman, R. Muenz and Y.G. Bekesi. Immunopathologic features of rapidly progressing breast cancer (RPBC) in Tunisia. Proc Am Assoc Cancer Res 21, 170 (1980) 45. R. Lloyd, P. P. Rosen, N.H. Sarkar, D. Jimenez, D.W. Kinne, C. Menendez-Botet, M.K. Schwartz. Muring mammary tumor virus related antigen in human male mammary carcinoma. Cancer (Phila.) 51, 654-661 (1983) 46. S.V. Litvinov, T.V. Golovkina. Expression of proteins immunologically related to murine mammary tumour virus (MMTV) core proteins in the cells of breast cancer continuous lines MCF-7, T47D, MDA-231 and cells from human milk. Acta Virol 33, 137-142 (1989) 47. S. Zotter, C. Kemmer, A. Lossnitzer, H. Grossmann, B.A. Johannsen. Mouse mammary tumour virus-related antigens in core-like density fractions from large samples of womens milk. Eur J Cancer, 16, 455-467 (1980) 48. N.K. Day, S.S. Witkin, N.H. Sarkar, D. Kinne, D.J. Jussawalla et al. Antibodies reactive with murine mammary tumor virus insera of patients with breast cancer: Geographic and family studies. Proc Natl Acad Sci USA 78, 2483-2487 (1981) 49. S.S. Witlin, N.H. Sarkar, D.W. Kinne, C.N. Breed, R.A, Good and N.K. Day. Antigens and antibodies cross-reactive to the murine mammary tumor virus in human breast cyst fluids. J Clin Invest 67, 216-222 (1981) 50. I. Keydar, T. Ohno, R. Nayak, R. Sweet, F. Simoni, F. Weiss, S. Karby, R. Mesa-Tejada , S. Spiegelman. Properties of retrovirus-like particles produced by a human breast carcinoma cell line: immunological relationship with mouse mammary tumor virus proteins. Proc Natl Acad Sci USA 81, 4188-4192 (1984) 51. R. Callahan, W. Drohan, S. Tronick, J. Schlom. Detection and cloning of human DNA sequences related to the mouse mammary tumor virus genome. Proc Natl Acad Sci USA 79, 5503-5507 (1982) 52. R. Axel, J. Schlom, S. Spiegelman. Presence in human breast cancer of RNA homologous to mouse mammary tumor virus RNA. Nature (Lond.) 235, 32-36 (1972) 53. R. Lidereau, R. Callahan, C. Dickson, G. Peters, C. Escot, I Ali. Amplification of the int-2 gene in primary human breast tumors. Oncogene Res 2, 285-291 (1988) 54. D.J. Zhou, G. Casey, M.J. Cline. Amplification of human int-2 in breast cancers and squamous carcinomas. Oncogene 2, 279-282 (1988) 55. D.S. Liscia, G.R. Merlo, C. Garrett, D. French, R. Marini-Constantini, R. Callahan. Expression of int-2 mRNA in human tumors amplified at the int-2 locus. Oncogene 4, 1219-1224 (1989) 56. S.L. Meyers, M.T. OBrien, T. Snith, J.P. Dudley. Analysis of the int-1, int-2, c-myc, and neu oncogenes in human breast carcinomas. Cancer Res 50, 5911-5918 (1990) 57. Y. Wang, J.F. Holland, I.J. Bleiweiss, S. Melana, X. Liu, I. Pelisson, A. Cantarella, K. Stellrecht, S. Mani, B.G-T. Pogo. Detection of mammary tumor virus ENV gene-like sequences in human breast cancer. Cancer Res 55, 5173-5179 (1995) 58. T.D. Bui, J. Rankin, K. Smith, E.L. Huguet, S. Ruben, T. Strachan, A.L. Harris, S. Lindsay. A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas. Oncogene 14, 1249-1253 (1997) |