[Frontiers in Bioscience 2, d27-42, January 1, 1997]
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CAVEAT LECTOR



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BTK, THE TYROSINE KINASE AFFECTED IN X-LINKED AGAMMAGLOBULINEMIA

Mauno Vihinen1, Pekka T. Mattsson2,3 and C. I. Edvard Smith2

1Department of Biosciences, Division of Biochemistry, P. O. Box 56, FIN-00014 University of Helsinki, Finland

2Center for BioTechnology, Department of Bioscience at Novum, Karolinska Institute, S-141 57 Huddinge and Department of Immunology, Microbiology, Pathology and Infectious Diseases (IMPI), Karolinska Institute, Huddinge University Hospital, S-141 86 Huddinge, Sweden

3Department of Biochemistry and Food Chemistry, University of Turku, Vatselankatu 2, Arcanum, FIN-20014 Turku, Finland

Received 11/24/96; Accepted 12/16/96; On-line 01/01/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Spectrum of infections and treatment
4. The XLA gene encodes a tyrosine kinase
5. Activation of Btk and its connection to signal transduction pathways
6. Structural consequences of Btk mutations
6.1. PH domain
6.2. TH domain
6.3. SH3 domain
6.4. SH2 domain
6.5. Kinase domain
7. Acknowledgements
8. References
9. Entire manuscript

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