[Frontiers in Bioscience 2, d43-48, February 1, 1997]

	[Frontiers in Bioscience 2, d43-48, February 1, 1997] Reprints PubMed CAVEAT LECTOR
	ROLE OF CHOLESTEROL IN THE REGULATION OF RENAL PHOSPHATE TRANSPORT Huamin Wang, Hubert Zajicek, Vijay Kumar, Paul Wilson, and Moshe Levi Department of Medicine, The University of Texas Southwestern Medical Center at Dallas and Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA Received 1/13/97; Accepted 1/13/97; On-line 02/01/96 5. SUMMARY In summary, in addition to the chemical and physical effects on the Na/Pi cotransport proteins at the level of the plasma membrane, in intact renal tubular cells cholesterol could also regulate Na/Pi cotransport activity by modulating Na/Pi mRNA level and/or BBM Na/Pi protein abundance (Table 1). Further studies in renal tubular cells grown in culture should elucidate the cellular and molecular mechanisms how perturbations in cholesterol metabolism and cholesterol content modulate Na/Pi cotransport activity.

[Frontiers in Bioscience 2, d43-48, February 1, 1997]
Reprints
PubMed
CAVEAT LECTOR

ROLE OF CHOLESTEROL IN THE REGULATION OF RENAL PHOSPHATE TRANSPORT

Huamin Wang, Hubert Zajicek, Vijay Kumar, Paul Wilson, and Moshe Levi

Department of Medicine, The University of Texas Southwestern Medical Center at Dallas and Department of Veterans Affairs Medical Center, Dallas, Texas 75216, USA

Received 1/13/97; Accepted 1/13/97; On-line 02/01/96

5. SUMMARY

In summary, in addition to the chemical and physical effects on the Na/Pi cotransport proteins at the level of the plasma membrane, in intact renal tubular cells cholesterol could also regulate Na/Pi cotransport activity by modulating Na/Pi mRNA level and/or BBM Na/Pi protein abundance (Table 1).

Further studies in renal tubular cells grown in culture should elucidate the cellular and molecular mechanisms how perturbations in cholesterol metabolism and cholesterol content modulate Na/Pi cotransport activity.