[Frontiers in Bioscience 2, d160-172, March 15, 1997]
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SIGNAL TRANSDUCTION IN PANCREATIC ß-CELLS: REGULATION OF INSULIN SECRETION BY INFORMATION FLOW IN THE PHOSPHOLIPASE C/PROTEIN KINASE C PATHWAY

Walter S. Zawalich, Marc Bonnet-Eymard, and Kathleen C. Zawalich

Yale University School of Nursing, 100 Church Street South, New Haven, CT 06536-0740 USA

Received 2/24/97; Accepted 2/27/97; On-line 3/15/97

9. REFERENCES

1. Henquin J-C. Cell biology of insulin secretion. In: Kahn CR, Weir GC, Eds: Joslin's Diabetes Mellitus. 13th ed. Lea & Febiger; Philadelphia 1994:56-80.

2. Newgard CB, McGarry JD. Metabolic coupling factors in pancreatic ß-cell signal transduction. Ann Rev Biochem 1995;64:689-719.

3. Laychock SG. Glucose metabolism, second messengers and insulin secretion. Life Sciences 1990;47:2307-2316.

4. Grodsky GM. A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling. J Clin Invest 1972;51(8):2047-2059.

5. Gerich JE, Charles MA, Grodsky GM. Characterization of the effects of arginine and glucose on glucagon and insulin release from the perfused rat pancreas. J Clin Invest 1974;54(4):833-841.

6. Curry DL. Insulin content and insulinogenesis by the perfused rat pancreas: effects of long term glucose stimulation. Endocrinology 1986;118(1):170-175.

7. Grill V, Adamson U, Cerasi E. Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. J Clin Invest 1978;61(4):1034-1043.

8. Malaisse WJ, Sener A, Boschero AC, Kawazu S, Devis G, Somers G. The stimulus-secretion coupling of glucose-induced insulin release. Cationic and secretory effects of menadione in the endocrine pancreas. Eur J Biochem 1978;87(11):111-120.

9. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979;6(3):E214-E223.

10. Tillil H, Shapiro ET, Rubenstein AH, Galloway JA, Polonsky KS. Reduction of insulin clearance during hyperglycemic clamp: dose-response study in normal humans. Diabetes 1988;37(10):1351-1357.

11. Van Haeften TW, Boonstra E, Veneman TF, Gerich JE, van der Veen EA. Dose-response characteristics for glucose-stimulated insulin release in man and assessment of influence of glucose on arginine-stimulated insulin release. Metabolism 1990;39(12):1292-1299.

12. Elahi D. In praise of the hyperglycemic clamp: a method for assessment of ß-cell sensitivity and insulin resistance. Diabetes Care 1996;19:278-286.

13. Loubatieres-Mariani MM, Chapal J, Alric R, Loubatieres A. Studies of the cholinergic receptor involved in the secretion of insulin using isolated perfused rat pancreas. Diabetologia 1973;9(6):439-476.

14. Zawalich WS, Takuwa N, Takuwa Y, Diaz VA, Rasmussen H. Interactions of cholecystokinin and glucose in rat pancreatic islets. Diabetes 1987;36:426-433.

15. Zawalich WS, Zawalich KC, Cline G, Shulman G, Rasmussen H. Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets. Diabetes 1993;42(6):843-50.

16. Zawalich WS, Diaz VA, Zawalich KC. Role of phosphoinositide metabolism in induction of memory in isolated perifused rat islets. Am J Physiol 1988;254:E609-E616.

17. O'Conner MDL, Landahl H, Grodsky GM. Comparison of storage- and signal-limited models of pancreatic insulin secretion. Am J Physiol 1980;238:R378-R389.

18. Zawalich WS, Zawalich KC, Rasmussen H. Cholinergic agonists prime the ß-cell to glucose stimulation. Endocrinology 1989;125(5):2400-6.

19. Zawalich WS, Diaz VA. Prior cholecystokinin exposure sensitizes islets of Langerhans to glucose stimulation. Diabetes 1987;36:118-122.

20. Zawalich WS. Time-dependent potentiation of insulin release induced by alpha-ketoisocaproate and leucine in rats: possible involvement of phosphoinositide hydrolysis. Diabetologia 1988;31:435-442.

21. Grill V, Adamson U, Rundfeldt M, Andersson S, Cerasi E. Glucose memory of pancreatic B and A2 cells. J Clin Invest 1979;64:700-707.

22. Zawalich WS, Zawalich KC. Influence of pyruvic acid methyl ester on rat pancreatic islets: Effects on insulin secretion, phosphoinositide hydrolysis and sensitization of the ß-cell. J Biol Chem 1997;272:3527-3531.

23. Sorensen RLC. Islet priming by phorbol ester. Horm Metab Res 1986;18:353-354.

24. Niki I, Tamagawa J, Niki H, Niki A, Koide T, Sakamoto N. Possible involvement of diacylglycerol-activated Ca2+-dependent glucose protein kinase in memory of rat pancreatic ß-cell. Acta Endocrinol 1988;118(2):204-208.

25. Parra-Covarrubias A, Rivera-Rodriguez I, Almaraz-Ugalde A. Cephalic phase of insulin secretion in obese adolescents. Diabetes 1971;20(12):800-802.

26. Teff KL, Levin BE, Engelman K. Oral sensory stimulation in men: effects on insulin, C-peptide, and catecholamines. Am J Physiol 1993;265:R1223-R1230.

27. Grodsky GM. A new phase of insulin secretion. How will it contribute to our understanding of ß-cell function? Diabetes 1989;38(6):673-678.

28. Grodsky GM, Bolaffi JL. Desensitization of the insulin-secreting beta cell. J Cell Biol 1992;48(1):3-11.

29. Rasmussen H, Zawalich KC, Ganesan S, Calle R, Zawalich WS. Physiology and pathophysiology of insulin secretion. [Review]. Diabetes Care 1990;13(6):655-66.

30. DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM: a balanced overview. Diabetes Care 1992;15(3):318-368.

31. Rossetti L, Shulman GI, Zawalich W, DeFronzo RA. Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats. J Clin Invest 1987;80(4):1037-44.

32. Rossetti L, Giaccari A, DeFronzo RA. Glucose toxicity. Diabetes Care 1990;13(6):610-630.

33. Zawalich WS, Zawalich KC, Rasmussen H. The conditions under which rat islets are labelled with [3H]inositol alter the subsequent responses of these islets to a high glucose concentration. Biochem J 1989;259(3):743-9.

34. Zawalich WS, Zawalich KC. Glucosamine-induced desensitization of beta-cell responses: possible involvement of impaired information flow in the phosphoinositide cycle. Endocrinology 1992;130(6):3135-42.

35. Zawalich WS, Zawalich KC, Kelley GG. Time-dependent effects of cholinergic stimulation on beta cell responsiveness. Eur J Physiol 1996;432(4):589-596.

36. Zawalich WS, Zawalich KC. Forskolin-induced desensitization of pancreatic ß-cell insulin secretory responsiveness: possible involvement of impaired information flow in the inositol-lipid cycle. Endocrinology 1990;126:2307-2312.

37. Bolaffi JL, Bruno Z, Heldt A, Grodsky GM. Characteristics of desensitization of insulin secretion in fully in vitro systems. Endocrinology 1988;122(5):1801-1809.

38. DeFronzo RA. The triumvirate: ß-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988;37:667-687.

39. Rasmussen H, Isales CM, Calle R, Throckmorton D, Anderson M, Gasalla-Herraiz J, McCarthy R. Diacylglycerol production, Ca2+ influx, and protein kinase C activation in sustained cellular responses. Endocr Rev 1995;16(5):649-681.

40. Henquin JC, Charles S, Nenquin M, Mathot F, Tamagawa T. Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes 1982;31(9):776-783.

41. Zawalich WS, Diaz VA, Zawalich KC. Influence of cAMP and calcium on [3H]inositol efflux, inositol phosphate accumulation, and insulin release from isolated rat islets [published erratum appears in Diabetes 1989 Mar;38(3):3]. Diabetes 1988;37(11):1478-83.

42. Axen KV, Schubart UK, Blake AD, Fleischer N. Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets. J Clin Invest 1983;72(1):13-21.

43. Gomez M, Curry DL. Potassium stimulation of insulin release by the perfused rat pancreas. Endocrinology 1973;92:1126-1134.

44. Henquin J-C, Lambert AE. Cationic environment and dynamics of insulin secretion. Diabetes 1974;23:933-942.

45. Kelley GG, Zawalich KC, Zawalich WS. Calcium and a mitochondrial signal interact to stimulate phosphoinositide hydrolysis and insulin secretion in rat islets. Endocrinology 1994;134:1648-1654.

46. MacDonald MJ. Elusive proximal signals of ß-cells for insulin secretion. Diabetes 1990;39(12):1461-1466.

47. Best L, Malaisse WJ. Stimulation of phosphoinositide breakdown in pancreatic islets by glucose and carbamylcholine. Biochem Biophys Res Commun 1983;116(1):9-16.

48. Zawalich WS, Zawalich KC. Phosphoinositide hydrolysis and insulin release from isolated perifused rat islets. Studies with glucose. Diabetes 1988;37(9):1294-300.

49. Vadakekalam J, Rabaglia M, Chen Q-H, Metz SA. Glucose-induced phosphoinositide hydrolysis. A requirement for GTP in calcium-induced phospholipase C activation in pancreatic islets. Am J Physiol 1996;271:E85-E95.

50. MacDonald MJ, Fahien LA, Mertz RJ, Rana RS. Effects of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets. Arch Biochem Biophys 1989;269(2):400-406.

51. Zawalich WS, Zawalich KC. Biochemical mechanisms involved in monomethyl succinate-induced insulin secretion. Endocrinology 1992;131(2):649-54.

52. Zawalich WS, Zawalich KC, Kelley GG. Regulation of insulin release by phospholipase C activation in mouse islets: differential effects of glucose and neurohumoral stimulation. Endocrinology 1995;136(11):4903-4909.

53. Rhee SG, Choi KD. Regulation of inositol phospholipid-specific phospholipase C isozymes. J Biol Chem 1992;267(18):12393-12396.

54. Zawalich WS. Regulation of insulin secretion by phosphoinositide-specific phospholipase C and protein kinase C activation. Diabetes Rev 1996;4(2):160-176.

55. Zawalich WS, Zawalich KC. Regulation of insulin secretion by phospholipase C. Am J Physiol 1996;271:E409-E416.

56. Best L, Malaisse WJ. Phosphatidylinositol and phosphatidic acid metabolism in response to neurotransmitter and hormonal stimuli. Biochem Biophys Acta 1983;750(1):157-163.

57. Kelley GG, Zawalich KC, Zawalich WS. Synergistic interaction of glucose and neurohumoral agonists to stimulate islet phosphoinositide hydrolysis. Am J Physiol 1995;269:E575-E582.

58. Zawalich WS, Zawalich KC, Rasmussen H. Interactions between lithium, inositol and mono-oleoylglycerol in the regulation of insulin secretion from isolated perifused rat islets. Biochem J 1989;262(2):557-61.

59. Charles MA, Lawecki J, Pictet R, Grodsky GM. Insulin Secretion. Interrelationships of glucose, cyclic adenosine 3':5'-monophosphate and calcium. J Biol Chem 1975;250(15):6134-6140.

60. Berridge MJ. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Ann Rev Biochem 1987;56:159-193.

61. Castagna M, Takai Y, Kaibuchi K, Sano K, Kikkawa U, Nishizuka Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem 1982;257(13):7847-7851.

62. Ganesan S, Calle R, Zawalich K, Greenawalt K, Zawalich W, Shulman GI, Rasmussen H. Immunocytochemical localization of alpha-protein kinase C in rat pancreatic ß-cells during glucose-induced insulin secretion. J Cell Biol 1992;119(2):313-24.

63. Ganesan S, Calle R, Zawalich K, Smallwood JI, Zawalich WS, Rasmussen H. Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci USA 1990;87:9893-9897.

64. Calle R, Ganesan S, Smallwood JI, Rasmussen H. Glucose-induced phosphorylation of myristoylated alanine-rich C kinase substrate (MARCKS) in isolated rat pancreatic islets. J Biol Chem 1992;267(26):18723-18727.

65. Zawalich WS, Zawalich KC, Ganesan S, Calle R, Rasmussen H. Influence of staurosporine on glucose-mediated and glucose-conditioned insulin secretion. Biochem J 1991;279:807-813.

66. Thams P, Capito K, Hedeskov CJ. Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C. Biochem J 1988;253:229-234.

67. Malaisse WJ, Sener A, Herchuelz A, Carpinelli AR, Poloczek P, Winand J, Castagna M. Insulinotropic effect of the tumor promoter 12-0-tetradecanoyl phorbol-13-acetate in rat pancreatic islets. Cancer Res 1980;40(10):3827-3831.

68. Easom RA, Hughes JH, Landt M, Wolf BA, Turk J, McDaniel ML. Comparison of effects of phorbol esters and glucose on protein kinase C activation and insulin secretion in pancreatic islets. Biochem J 1989;264(1):27-33.

69. Hii CST, Jones PM, Persaud SJ, Howell SL. A re-assessment of the role of protein kinase C in glucose-stimulated insulin secretion. Biochem J 1987;246(2):489-494.

70. Zawalich W, Brown C, Rasmussen H. Insulin secretion: combined effects of phorbol ester and A23187. Biochem Biophys Res Commun 1983;117:448-455.

71. Zawalich WS, Zawalich KC, Kelley GG. Effects of short term culturing on islet phosphoinositide and insulin secretory responses to glucose and carbachol. Acta Diabetologica 1995;32:158-164.

72. Wolf BA, Easom RA, McDaniel ML, Turk J. Diacylglycerol synthesis de novo from glucose by pancreatic islets isolated from rats and humans. J Clin Invest 1990;85(2):482-490.

73. Malaisse-Lagae F, Sener A, Malaisse WJ. Can desensitization of the ß-cell to glucose be simulated in cultured pancreatic islets? Acta Diabetol Lat 1987;24:17-25.

74. Metz SA. Is protein kinase C required for physiologic insulin release? Diabetes 1988;37(1):3-7.

75. Deeney JT, Cunningham BA, Chheda S, Bokvist K, Juntti-Berggren L, Lam K, Korchak HM, Corkey BE, Berggren P-O. Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem 1996;271:18154-18160.

76. Nishizaki T, Walent JH, Kowalchyk JA, Martin TJ. A key role for a 145-kDa cytosolic protein in the stimulating of Ca2+-dependent secretion by protein kinase C. J Biol Chem 1992;267(33):23972-23981.

77. Lenzen S. Insulin secretion by isolated perfused rat and mouse pancreas. Am J Physiol 1979;236(4):E391-E400.

78. Berglund O. Different dynamics of insulin secretion in the perfused pancreas of the mouse and rat. Acta Endocrinol 1980;93(1):54-60.

79. Pagliara AS, Stillings SN, Hover B, Martin DM, Matschinsky FM. Glucose modulation of amino acid-induced glucagon and insulin release in the isolated perfused rat pancreas. J Clin Invest 1974;54:819-932.

80. Ma MYH, Wang J, Rodd GG, Bolaffi JL, Grodsky GM. Differences in insulin secretion between rat and mouse islets: role of cAMP. Eur J Endocrinol 1995;132(3):370-376.

81. Noda M, Komatsu M, Sharp GWG. The BHC-9 pancreatic ß-cell line preserves the characteristics of progenitor mouse islets. Diabetes 1996;45:1766-1773.

82. Elahi D, Muller DC, McAloon-Dyke M, Tobin JD, Andres R. The effect of age on insulin response and glucose utilization during four hyperglycemic plateaus. Experimental Gerontology 1993;28:393-409.

83. Berglund O. Lack of glucose-induced priming of insulin release in the perfused mouse pancreas. J Endocrinol 1987;114(2):185-189.

84. Cerasi E. Potentiation of insulin release by glucose in man I. Quantitative analysis of the enhancement of glucose-induced insulin secretion by pretreatment with glucose in normal subjects. Acta Endocrinol 1975;79:483-501.

85. Cerasi E. Potentiation of insulin release by glucose in man II. Role of the insulin response, and enhancement of stimuli other than glucose. Acta Endocrinol 1975;79:502-510.

86. Zawalich WS. Modulation of insulin secretion from beta-cells by phosphoinositide-derived second-messenger molecules. [A Review]. Diabetes 1988;37(2):137-41.

87. Zawalich WS. Multiple effects of increases in phosphoinositide hydrolysis on islets and their relationship to changing patterns of insulin secretion. Diabetes Research 1990;13:101-111.

88. Zawalich WS, Zawalich KC. Species differences in the induction of time dependent potentiation of insulin secretion. Endocrinology 1996;137:1664-1669.

89. Wiedenkeller DE, Sharp GWG. Effects of forskolin on insulin release and cAMP content in rat pancreatic islets. Endocrinology 1983;113(6):2311-2313.

90. Rhee SG, Suh R-G, Ryu S-H, Lee SY. Studies of inositol phospholipid-specific phospholipase C. Science 1989;244(4904):540-550.

91. Ryu SO, Kim U-H, Wahl WI, Brown AB, Carpenter G, Huang K-P, Rhee SG. Feedback regulation of phospholipase C-b by protein kinase C. J Biol Chem 1990;265(29):17941-17945.

92. LeStunff C, Borgnères P. Early changes in postprandial insulin secretion, not in insulin sensitivity, characterize juvenile obesity. Diabetes 1994;43(5):696-702.

93. Aronoff SL, Bennett PH, Gorden P, Rushforth N, Miller M. Unexplained hyperinsulinemia in normal and "prediabetic" Pima Indians compared with normal controls. Diabetes 1977;26(9):827-840.

94. Chen N-G, Romsos DR. Enhanced sensitivity of pancreatic islets from preobese two-week old ob/ob mice to neurohumoral stimulation of insulin secretion. Endocrinology 1995;136(2):505-511.

95. Tassava TM, Okuda T, Romsos DR. Insulin secretion from ob/ob mouse pancreatic islets: Effects of neurotransmitters. Am J Physiol 1992;262:E338-E343.

96. Zawalich WS. Signal transduction in isolated islets from the ob/ob mouse: enhanced sensitivity of protein kinase C to stimulation. Biochem Biophys Res Commun 1996;223:618-623.

97. Cusin I, Rohner-Jeanrenaud F, Terrattaz J, Jeanrenaud B. Hyperinsulinemia and its impact on obesity and insulin resistance. Int J Ob 1992; 16 (suppl. 4):S1-S11.

98. Mandarino L, Baker B, Rizza R, Genest J, Gerich J. Infusion of insulin impairs human adipocyte glucose metabolism in vitro without decreasing adipocyte insulin receptor binding. Diabetologia 1984;27(3):358-363.

99. Gavin JR, Roth J, Neville J, D.M., DeMeyts P, Buell DN. Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci USA 1974;71(1):84-88.

100. Zawalich WS, Kelley GG. The pathogenesis of NIDDM: the role of the pancreatic beta cell. Diabetologia 1995;38:986-991.

101. Zawalich WS, Zawalich KC, Shulman GI, Rossetti L. Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets. Endocrinology 1990;126(1):253-60.

102. Becker TC, Noel RJ, Johnson JH, Lynch RM, Hirose H, Tokuyama Y, Bell GI, Newgard CB. Differential effects of overexpressed glucokinase and hexokinase I in isolated islets. J Biol Chem 1996;271(1):390-394.