[Frontiers in Bioscience 2, d160-172, March 15, 1997]

	[Frontiers in Bioscience 2, d160-172, March 15, 1997] Reprints PubMed CAVEAT LECTOR
	SIGNAL TRANSDUCTION IN PANCREATIC ß-CELLS: REGULATION OF INSULIN SECRETION BY INFORMATION FLOW IN THE PHOSPHOLIPASE C/PROTEIN KINASE C PATHWAY Walter S. Zawalich, Marc Bonnet-Eymard, and Kathleen C. Zawalich Yale University School of Nursing, 100 Church Street South, New Haven, CT 06536-0740 USA Received 2/24/97; Accepted 2/27/97; On-line 3/15/97 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Multiple effects of glucose on the pancreatic ß-cell 3.1 Acute regulation of insulin release 3.2 Fail-safe regulation of insulin secretion and time-dependent potentiation 3.3 Time-dependent suppression of insulin release 4. Glucose-induced insulin secretion: role of phospholipase C activation 4.1 Effects of glucose on PLC-mediated phosphoinositide (PI) hydrolysis 4.2 PLC isozymes in islets and their activation 5. Glucose-induced insulin secretion: role of protein kinase C activation 5.1 Protein kinase C activation in freshly studied rat islets 5.2 Protein kinase C activation and glucose-induced insulin secretion from cultured islets 5.3 Insulin secretion from PKC-depleted islets 6. Species differences in glucose-induced insulin secretion 6.1 Glucose-induced insulin release from mouse islets 6.2 PLC activation in mouse islets 6.3 Time-dependent potentiation in mouse islets 6.4 Glucose fails to induce time-dependent suppression in mouse islets 7. The beta cell, obesity and NIDDM 8. Summary and Perspectives 9. References 10. Entire manuscript Key words: Phospholipase C, protein kinase C, insulin secretion, islets, ß-cell, phosphoinositide hydrolysis, time-dependent potentiation, time-dependent suppression Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d160-172, March 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

SIGNAL TRANSDUCTION IN PANCREATIC ß-CELLS: REGULATION OF INSULIN SECRETION BY INFORMATION FLOW IN THE PHOSPHOLIPASE C/PROTEIN KINASE C PATHWAY

Walter S. Zawalich, Marc Bonnet-Eymard, and Kathleen C. Zawalich

Yale University School of Nursing, 100 Church Street South, New Haven, CT 06536-0740 USA

Received 2/24/97; Accepted 2/27/97; On-line 3/15/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Multiple effects of glucose on the pancreatic ß-cell: 3.1 Acute regulation of insulin release; 3.2 Fail-safe regulation of insulin secretion and time-dependent potentiation; 3.3 Time-dependent suppression of insulin release
4. Glucose-induced insulin secretion: role of phospholipase C activation: 4.1 Effects of glucose on PLC-mediated phosphoinositide (PI) hydrolysis; 4.2 PLC isozymes in islets and their activation
5. Glucose-induced insulin secretion: role of protein kinase C activation: 5.1 Protein kinase C activation in freshly studied rat islets; 5.2 Protein kinase C activation and glucose-induced insulin secretion from cultured islets; 5.3 Insulin secretion from PKC-depleted islets
6. Species differences in glucose-induced insulin secretion: 6.1 Glucose-induced insulin release from mouse islets; 6.2 PLC activation in mouse islets; 6.3 Time-dependent potentiation in mouse islets; 6.4 Glucose fails to induce time-dependent suppression in mouse islets
7. The beta cell, obesity and NIDDM
8. Summary and Perspectives
9. References
10. Entire manuscript

Key words: Phospholipase C, protein kinase C, insulin secretion, islets, ß-cell, phosphoinositide hydrolysis, time-dependent potentiation, time-dependent suppression

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.