[Frontiers in Bioscience 2, d527-537, November 1, 1997]
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CAVEAT LECTOR




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CELLULAR MECHANISMS OF FELINE IMMUNODEFICIENCY VIRUS (FIV)-INDUCED NEUROPATHOGENESIS

Elisabeth Zenger, Evelyn Tiffany-Castiglioni, and Ellen W. Collisson

Department of Medicine, UCSF AIDS Program, San Francisco General Hospital, University of California, San Francisco, California (Zenger) and the Departments of Veterinary Anatomy and Public Health (Tiffany-Castiglioni) and Pathobiology (Collisson), College of Veterinary Medicine, Texas A&M University, College Station, Texas.

Received 10/7/97 Accepted 10/23/97

TABLE OF CONTENTS


1. Abstract
2. Introduction
3. A role for microglia and/or macrophages?
4. A role for astroglia?
4.1. Lymphocyte-facilitated astroglial infection by neurovirulent FIV
4.2. FIV-associated cytotoxicity and neurotoxicity
4.2.1. Laser cytometric analysis of FIV-associated cytotoxicity
4.2.2. Excitotoxicity in the neuropathogenesis of FIV
5. Perspectives
6. Acknowledgements
7. References
8. Entire manuscript

Key words: Feline immunodeficiency virus, Nervous system, Astrocyte, Glutamate

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