[Frontiers in Bioscience 2, e34-40, August 1, 1997]|
PANCREAS TRANSPLANTATION: INDICATIONS, CLINICAL MANAGEMENT, AND OUTCOMES
John P. Leone, MD, PhD1, Abhinav Humar1 , Rainer W. G. Gruessner, MD, PhD2, and David E.R. Sutherland, MD3
1Transplant Fellow, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, 2Professor & Chief, Section of Pancreatic Transplantation, Department of Surgery University of Minnesota, Minneapolis, Minnesota, 3Professor & Chief, Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota
Received 6/15/97; Accepted 6/23/97; On-line 7/25/97
4. ORGAN AVAILABILITY & CONTRAINDICATIONS TO DONATION
Pancreata can be procured from virtually every available cadaver from which other organs are retrieved. Presently, the standard of practice is to obtain the kidneys, liver, and pancreas from a single donor. However, the pancreas can be technically difficult to procure due to its anatomical location and vascular anatomy. Rarely, the pancreas may not be recovered if the liver is at risk during organ procurement. Similarly, if small bowel transplantation continues to progress at its present pace, modifications in procurement technique will have to accommodate the shared blood supply of the small intestine and pancreas.
Contraindications to the use of a donor pancreas include history of diabetes mellitus (Types 1 or 2), malignancy, acute pancreatitis, injury to the pancreas occurring during procurement, and advanced donor age (9).