[Frontiers in Bioscience 2, e34-40, August 1, 1997]

	[Frontiers in Bioscience 2, e34-40, August 1, 1997] Reprints PubMed CAVEAT LECTOR
	PANCREAS TRANSPLANTATION: INDICATIONS, CLINICAL MANAGEMENT, AND OUTCOMES John P. Leone, MD, PhD¹, Abhinav Humar¹ , Rainer W. G. Gruessner, MD, PhD², and David E.R. Sutherland, MD³ ^{1Transplant Fellow, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, ²Professor & Chief, Section of Pancreatic Transplantation, Department of Surgery University of Minnesota, Minneapolis, Minnesota, ³Professor & Chief, Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota Received 6/15/97; Accepted 6/23/97; On-line 7/25/97} 4. ORGAN AVAILABILITY & CONTRAINDICATIONS TO DONATION Pancreata can be procured from virtually every available cadaver from which other organs are retrieved. Presently, the standard of practice is to obtain the kidneys, liver, and pancreas from a single donor. However, the pancreas can be technically difficult to procure due to its anatomical location and vascular anatomy. Rarely, the pancreas may not be recovered if the liver is at risk during organ procurement. Similarly, if small bowel transplantation continues to progress at its present pace, modifications in procurement technique will have to accommodate the shared blood supply of the small intestine and pancreas. Contraindications to the use of a donor pancreas include history of diabetes mellitus (Types 1 or 2), malignancy, acute pancreatitis, injury to the pancreas occurring during procurement, and advanced donor age (9).

[Frontiers in Bioscience 2, e34-40, August 1, 1997]
Reprints
PubMed
CAVEAT LECTOR

PANCREAS TRANSPLANTATION: INDICATIONS, CLINICAL MANAGEMENT, AND OUTCOMES

John P. Leone, MD, PhD¹, Abhinav Humar¹ , Rainer W. G. Gruessner, MD, PhD², and David E.R. Sutherland, MD³
^{1Transplant Fellow, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, ²Professor & Chief, Section of Pancreatic Transplantation, Department of Surgery University of Minnesota, Minneapolis, Minnesota, ³Professor & Chief, Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota

Received 6/15/97; Accepted 6/23/97; On-line 7/25/97}

4. ORGAN AVAILABILITY & CONTRAINDICATIONS TO DONATION

Pancreata can be procured from virtually every available cadaver from which other organs are retrieved. Presently, the standard of practice is to obtain the kidneys, liver, and pancreas from a single donor. However, the pancreas can be technically difficult to procure due to its anatomical location and vascular anatomy. Rarely, the pancreas may not be recovered if the liver is at risk during organ procurement. Similarly, if small bowel transplantation continues to progress at its present pace, modifications in procurement technique will have to accommodate the shared blood supply of the small intestine and pancreas.

Contraindications to the use of a donor pancreas include history of diabetes mellitus (Types 1 or 2), malignancy, acute pancreatitis, injury to the pancreas occurring during procurement, and advanced donor age (9).