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WEEKLY PACLITAXEL AS A RADIATION SENSITIZER FOR LOCALLY ADVANCED GASTRIC AND PANCREATIC CANCERS:THE BROWN UNIVERSITY ONCOLOGY GROUP EXPERIENCE
William M. Sikov, MD and Howard Safran, MD
Department of Medicine, The Miriam Hospital and the Brown University School of Medicine, Providence, RI
Received 3/24/97 Accepted 4/3/97; On-line 5/1/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 2.1. Background
- 2.2. Paclitaxel
- 2.3. Paclitaxel, radiation and the cell cycle
- 2.4. Paclitaxel as a radiation sensitizer in NSCLC
- 2.5. Paclitaxel/RT is unaffected by p53 mutations in NSCLC
- 3. Phase I study of paclitaxel/RT for gastric and pancreatic cancer
- 4. Phase II studies of neoadjuvant paclitaxel/RT in locally advanced gastric and pancreatic cancers
- 4.1. Preliminary results
- 4.2. Activity of paclitaxel/RT in pancreatic and gastric tumors with p53 mutations
- 5. Future directions
- 6. Acknowledgment
- 7. References
- 8. Entire manuscript
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