[Frontiers in Bioscience 3, d408-418, March 27, 1998]

	[Frontiers in Bioscience 3, d408-418, March 27, 1998] Reprints PubMed CAVEAT LECTOR
	DNA INVERTED REPEATS AND HUMAN DISEASE John J. Bissler The Children's Hospital Research Foundation, Cincinnati, Ohio TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Inverted Repeats 4.. Cruciform Formation 5. In Vivo Formation of Cruciforms 5.1. Chemical Modification of the Hairpin Loop 5.2. Protein Recognition of the Extruded Hairpin 5.2.1. Antibody Studies 5.2.2. Endonuclease 5.3. Chemical Cross-linking 6. Biological Roles of Inverted Repeats 6.1. RNA Effects 6.2. DNA Effects 7. Role of Inverted Repeats in Mutagenesis 7.1. Palindrome Mediated Mutagenesis 7.2. Quasipalindrome Mediated Mutagenesis 7.3. Diseases Associated with Imperfect Inverted Repeats 7.3.1. Hereditary Angioneurotic Edema 7.3.2. Triplet Repeat Mediated Diseases 7.3.3. Duchenne Muscular Dystrophy 7.3.4. Osteogenesis Imperfecta 7.3.5. Antithrombin Deficiency 7.3.6. Silent Serum Cholinesterase 7.3.7. Lesch-Nyhan Syndrome 7.3.8. Kearn-Sayre Syndrome 7.3.9. Biotinase Deficiency 7.3.10. Familial Hypercholesterolemia 8. Perspectives 9. Acknowledgments 10. References 11. Entire manuscript Key words: Molecular Biology, DNA Structure, Inverted Repeat, Cruciform, Quasipalindrome, Mutagenesis, Hairpin Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d408-418, March 27, 1998]
Reprints
PubMed
CAVEAT LECTOR

DNA INVERTED REPEATS AND HUMAN DISEASE

John J. Bissler

The Children's Hospital Research Foundation, Cincinnati, Ohio

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Inverted Repeats
4.. Cruciform Formation
5. In Vivo Formation of Cruciforms: 5.1. Chemical Modification of the Hairpin Loop
5.2. Protein Recognition of the Extruded Hairpin
5.2.1. Antibody Studies
5.2.2. Endonuclease
5.3. Chemical Cross-linking
6. Biological Roles of Inverted Repeats: 6.1. RNA Effects
6.2. DNA Effects
7. Role of Inverted Repeats in Mutagenesis: 7.1. Palindrome Mediated Mutagenesis
7.2. Quasipalindrome Mediated Mutagenesis
7.3. Diseases Associated with Imperfect Inverted Repeats
7.3.1. Hereditary Angioneurotic Edema
7.3.2. Triplet Repeat Mediated Diseases
7.3.3. Duchenne Muscular Dystrophy
7.3.4. Osteogenesis Imperfecta
7.3.5. Antithrombin Deficiency
7.3.6. Silent Serum Cholinesterase
7.3.7. Lesch-Nyhan Syndrome
7.3.8. Kearn-Sayre Syndrome
7.3.9. Biotinase Deficiency
7.3.10. Familial Hypercholesterolemia
8. Perspectives
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Molecular Biology, DNA Structure, Inverted Repeat, Cruciform, Quasipalindrome, Mutagenesis, Hairpin

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.