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[Frontiers in Bioscience 3, a27-31, May 11, 1998] Reprints PubMed CAVEAT LECTOR |
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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN; PART I; A CALCIUM DEFICIT HYPOTHESIS Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 3361 and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744 Received 4/27/98 Accepted 5/1/98 5. REFERENCES 1. Selkoe, D. J. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271, 18295-18298 (1996) 2. Cordell, B. beta-Amyloid formation as a potential therapeutic target for Alzheimer's disease. Ann Rev Pharmacol Toxicol 34, 69-89 (1994) 3. Yankner, B. A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932 (1996) 4. Goedert, M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Trends Neurosci 16, 160-165 (1993). 5. Chen, M. Alzheimer's a -secretase may be a calcium-dependent protease. FEBS Lett 417, 163-167 (1997) 6. Lannfelt, L. Basun, H. Wahlund, L-O. 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