[Frontiers in Bioscience 3, a27-31, May 11, 1998]
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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN; PART I; A CALCIUM DEFICIT HYPOTHESIS

Ming Chen

Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 3361 and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744

Received 4/27/98 Accepted 5/1/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Calcium-dependent a-secretase
3.2. Neurofibrillary tangles
3.3. Neurotransmission and memory formation
3.4. The drug effects
3.5. The basis of the current hypothesis
3.6. A "biphasic" proposal for calcium alterations in AD
3.7. Predictions and experimental testing
4. Acknowledgments
5. References
6. Entire manuscript

Key words: Alzheimer's disease, Calcium, ß-amyloid, Neurofibrillary tangles, Calpain, Presenilin

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