[Frontiers in Bioscience 3, a27-31, May 11, 1998]

	[Frontiers in Bioscience 3, a27-31, May 11, 1998] Reprints PubMed CAVEAT LECTOR
	THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN; PART I; A CALCIUM DEFICIT HYPOTHESIS Ming Chen Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 3361 and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744 Received 4/27/98 Accepted 5/1/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Discussion 3.1. Calcium-dependent a-secretase 3.2. Neurofibrillary tangles 3.3. Neurotransmission and memory formation 3.4. The drug effects 3.5. The basis of the current hypothesis 3.6. A "biphasic" proposal for calcium alterations in AD 3.7. Predictions and experimental testing 4. Acknowledgments 5. References 6. Entire manuscript Key words: Alzheimer's disease, Calcium, ß-amyloid, Neurofibrillary tangles, Calpain, Presenilin Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, a27-31, May 11, 1998]
Reprints
PubMed
CAVEAT LECTOR

THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN; PART I; A CALCIUM DEFICIT HYPOTHESIS

Ming Chen

Department of Pharmacology and Therapeutics, University of South Florida, College of Medicine, Tampa, Florida 3361 and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744

Received 4/27/98 Accepted 5/1/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion: 3.1. Calcium-dependent a-secretase
3.2. Neurofibrillary tangles
3.3. Neurotransmission and memory formation
3.4. The drug effects
3.5. The basis of the current hypothesis
3.6. A "biphasic" proposal for calcium alterations in AD
3.7. Predictions and experimental testing
4. Acknowledgments
5. References
6. Entire manuscript

Key words: Alzheimer's disease, Calcium, ß-amyloid, Neurofibrillary tangles, Calpain, Presenilin

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.