[Frontiers in Bioscience, a32-37, June 8, 1998]
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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN - PART II: THERAPEUTIC RATIONALE

Ming Chen

Department of Pharmacology and Therapeutics, University of South Florida , College of Medicine, Tampa, Florida 33612, and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744

Received 5/15/98 Accepted 5/24/98

TABLE OF CONTENTS

1. Abstract

2. Introduction
3. Discussion
3.1. Calcium deficit in AD
3.2. Synapse losses vs. plaques and tangles
3.3. Roles of presenilins
3.4. Targets of pharmacological intervention
4. Acknowledgements
5. References
6. Entire manuscript

Key words: Alzheimer's disease, Calcium, ß-Amyloid, Neurofibrillary tangles, Synapse, Presenilin, Prevention

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