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[Frontiers in Bioscience 3, a47-51, June 17, 1998] Reprints PubMed CAVEAT LECTOR |
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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN - PART III: ANIMAL MODEL
Department of Pharmacology and Therapeutics, University of South Florida , College of Medicine, Tampa, Florida 33612, and Medical Research Service (151), Bay Pines VA Medical Center, St. Petersburg, Florida 33744 Received 6/9/98 Accepted 6/17/98 6. REFERENCES 1. Selkoe, D. J. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271, 18295-18298 (1996) 2. Yankner, B. A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932 (1996) 3. Trojanowski, J. Q. and Lee, V. M-Y. Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesion: focusing on phosphatases. FASEB J 9, 1570-1576 (1995) 4. Terry, R. D. Masliah, E. Salmon, D. P. Butters, N. DeTeresa, R. Hill, R. Hansen, L. A. and Katzman, R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30, 572-580 (1991) 5. Greenberg, B. D, Savage, M. J, Howland, D. S. Ali, S. M. Siedlak, S. 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