[Frontiers in Bioscience 3, a66-75, December 15, 98]
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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN - PART IV: CAN CALPAIN ACT AS a-SECRETASE?

Ming Chen1 and Hugo L. Fernandez2

1,2 Neuroscience Research Laboratory, Medical Research Service (151), Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA. 2 Department of Pharmacology and Therapeutics; Department of Neurology and bDepartment of Physiology and Biophysics, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

Received 11/25/98 Accepted 12/4/98

5. ACKNOWLEDGEMENTS

We wish to thank Jacques Durr, Alfred Stracher, Gang Liu, Carole Smith-Deland, Xin-Ming Wang and Mary Savage (Cephalon, Inc.) for stimulating discussions, and Rob Giles for artwork.