[Frontiers in Bioscience 3, a66-75, December 15, 98]
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CAVEAT LECTOR




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THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN - PART IV: CAN CALPAIN ACT AS a-SECRETASE?

Ming Chen1 and Hugo L. Fernandez2

1,2 Neuroscience Research Laboratory, Medical Research Service (151), Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA. 2 Department of Pharmacology and Therapeutics; Department of Neurology and bDepartment of Physiology and Biophysics, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

Received 11/25/98 Accepted 12/4/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Discussion
3.1. Calcium-dependent a-secretase
3.2. "Profile" of ß- and g-secretases
3.3. a-Secretase and calpain
3.4. Evidence in favor of calpain as a-secretase
3.5. Evidence against calpain as a-secretase
3.6. Can calpain act as a-secretase?
3.7. A theoretical model for calpain in APP processing
3.8. Experimental testing of the model
3.9. Can presenilins regulate calpain?
4. Conclusions
5. Acknowledgements
6. References
7. Entire manuscript

Key words: Alzheimer's disease, Amyloid, Calcium, Calpain, Presenilin