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[Frontiers in Bioscience 3, a1-10, January 1, 1998] Reprints PubMed CAVEAT LECTOR |
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OPTICAL SPECTROSCOPY OF BREAST BIOPSIES AND HUMAN BREAST CANCER XENOGRAFTS IN NUDE MICE General Electric Corporate Research and Development, One Research Circle, Niskayuna, NY 12309 Received 11/25/97 Accepted 12/5/97 6. ACKNOWLEDGEMENTS The breast biopsy samples were obtained from Dr. H. Singh at Ellis Hospitial in Schenectady, NY. In the initial phases of the project, pathologist Dr. Maleka Hussain supplied breast biopsies, formalin fixed breast tissue and prepared slide mounted samples for optical extinction measurements. Dr. Hussain also provided a second diagnosis of the pathology of selected samples thereby allowing an assessment of errors caused by the heterogeneity of the samples. The mouse model tumors were implanted and grown by M. Huang in the laboratories of D. J. Castro, M.D., Ph. D. and R. Saxton, Ph. D. at UCLA School of Medicine. N. Joongwaard, T. L. Pusheck, M.D and M. Huang of Dr. Castro's group handled the mice during the In vivo model tumor experiments which were performed in their laboratories in Los Angeles. Dr. Puscheck performed the surgery on the mice. Many long and informative sessions were held with Dr. Saxton which aided in the understanding and the design of the In vivo spectroscopic experiments on the nude mice. The cancer cell cultures were prepared by Drs. C. Keese and I. Giaever at Rensselaer Polytechnic Institute. The Guided Wave remote spectrophotometer was loaned by Mr. David Geller, manufacturer's representative of the Perstorp NIR Group. |