[Frontiers in Bioscience, 3, a52-57, September 15, 1998]
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CAVEAT LECTOR




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APOPTOSIS IN THE DEVELOPING CEREBELLUM OF THE THYROID HORMONE DEFICIENT RAT

Qianxun Xiao and Vera M. Nikodem

Mechanism of Gene Regulation Section, Genetics and Biochemistry Branch, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Dr. MSC 1766, Bethesda, MD 20892-1766

Received 8/20/98 Accepted 9/7/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Materials and Methods
3.1. Animals and tissue preparation
3.2. In situ apoptosis detection
3.3. Detection of TSH
4. Results
4.1. Evaluation of DNA fragmentation in cerebellar granular cells of developing euthyroid rats
4.2. Evaluation of DNA fragmentation in cerebellar granular cells of developing hypothyroid rats
5. Discussion
6. Acknowledgment
7. References
8. Entire manuscript

Key words: Apoptosis, Thyroid Hormone, Developing Cerebellum, Hypothyroid Rat, Brain

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