[Frontiers in Bioscience 3, d237-249, February 15, 1998]
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HERPES SIMPLEX VIRUS TYPE 2: UNIQUE BIOLOGICAL PROPERTIES INCLUDE NEOPLASTIC POTENTIAL MEDIATED BY THE PK DOMAIN OF THE LARGE SUBUNIT OF RIBONUCLEOTIDE REDUCTASE

Laure Aurelian1,2

1Virology/Immunology Laboratories, Departments of Pharmacology and Experimental Therapeutics and Microbiology, The University of Maryland School of Medicine, Ten South Pine Street, Baltimore MD 21201, USA 2Department of Biochemistry, The Johns Hopkins School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA

Received 12/8/97 Accepted 1/14/98

TABLE OF CONTENTS
1. Abstract
2. Introduction
3. The HSV virion and its genome
4. HSV genes and the replicative cycle
5. HSV gene expression and latency
6. HSV2 RR1 is a chimera that contains cellular sequences
7. RR1 PK codes for a novel kinase activity which is required for neoplastic transformation
8. Transformation by HSV-2 RR1 PK involves activation of the ras signaling pathway
9. HSV-2 causes hyperproliferative lesions in human patients
10. Conclusions
11. Acknowledgments
12. References
13. Entire manuscript

Key words: Herpes simplex virus type 2, Sexually transmitted diseases, Genital lesions, Viral genes, Protein kinase, Ribonucleotide reductase, Growth factor receptor, Oncogene, Transformation, Neoplasia, Latency, Gene therapy, Antisense chemotherapy