[Frontiers in Bioscience, 3, d431-435, April 16, 98]
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THE NEURO-IMMUNOLOGICAL INTERFACE IN AN EVOLUTIONARY PERSPECTIVE: THE DYNAMIC RELATIONSHIP BETWEEN EFFECTOR AND RECOGNITION SYSTEMS

Enzo Ottaviani1, Silvana Valensin2 and Claudio Franceschi2,3

1Department of Animal Biology, University of Modena via Berengario 14 41100 Modena, 2Department of Biomedical Sciences, General Pathology Section, University of Modena, and 3INRCA, 61100 Ancona, Italy

Received 3/26/98 Accepted 4/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. The enigma of the immune system
3. The immune-neuroendocrine effector system: the role of the macrophage
4. The invertebrate recognition system
5. The relationship between recognition and pathogens
6. The increasing complexity of the recognition system
7. The integration of the old effector system and the new repertoires of recognition units
8. Acknowledgment
9. References
9. Entire manuscript

Key words: Immune-neuroendocrine system, Macrophage, T cells, B cells, T cell repertoire, B cell repertoire, Thymus, MHC, Evolution