[Frontiers in Bioscience 3, d746-756. July 28, 1998]
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IgE-MEDIATED DESENSITIZATION IN HUMAN BASOPHILS AND MAST CELLS

Donald MacGlashan, Jr., Sandra Lavens-Phillips, and Katsushi Miura

Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224

Received 5/28/98 Accepted 6/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Is Secretion Self-Limiting?
4. Relationship between desensitization and release
5. Specificity of Desensitization
6. Underlying Mechanisms of Desensitization
6.1. Extracellular Negative Feedback?
6.2. Receptor loss from the cell surface?
6.3. Negative Regulation by Protein Kinase C?
6.4. Down-regulation during active secretion
6.5. Alternative Mechanisms
7. Summary
8. References
9. Entire manuscript

Key words: Allergy, Immediate Hypersensitivity, Signal Transduction, Mediators, Down-Regulation