[Frontiers in Bioscience 3, d769-780, August 1, 1998]
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G-PROTEIN COUPLED RECEPTORS IN BONE

Wayne B. Bowler1, James A. Gallagher and Graeme Bilbe2

1 Human Bone Cell Research Group, Department of Human Anatomy and Cell Biology, University of Liverpool, England, L69 3GE 2 Novartis Pharma A.G., Postfach, K681.4.43, CH-4002 Basel, Switzerland

Received 1/16/98 Accepted 2/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Seven transmembrane domain receptors
4. G-proteins
5. G protein coupled receptors expressed by osteoblasts
5.1. PTH/PTHrP receptor
5.2. Adenosine receptor
5.3. Beta-adrenergic receptor
5.4. P2Y receptors
5.5. Prostaglandin E2 receptor
5.6. Orphan receptor
5.7. Angiotensin II receptor
5.8. Calcium sensing receptor
6. G protein coupled receptors expressed by osteoclasts
6.1. Calcitonin receptor
6.2. P2Y receptor
6.3. Calcium sensing receptor
7. Perspective
8. References
9. Entire manuscript

Key words:

G-protein, Receptor, Osteoblast, Osteoclast