[Frontiers in Bioscience 3, d804-816, August 1, 1998]
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MAP KINASE SIGNALING CASCADES AND GENE EXPRESSION IN OSTEOBLASTS

Robert A. Hipskind1 and Graeme Bilbe2

1 Institut de Genetique Moleculaire de Montpellier, CNRS, 1919 Route de Mende, 34293 Montpellier cedex 5, France 2 Novartis Pharma A.G., Postfach, K681.4.43, CH-4002 Basel, Switzerland

Received 1/16/98 Accepted 2/17/ 98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Early events in osteoblast proliferation and differentiation
4. The human c-fos promoter
5. MAP kinase signaling cascades
5.1. ERKs
5.2. SAPK/JNKs
5.3. p38s
5.4. MAPK cascades in osteoblasts
5.5. MAPK cascades in vivo
6. AP-1
6.1. AP1 as a key regulatory point of MAPK cascades
6.2. AP-1 and MAP kinase pathways in osteoblasts
7. Perspective
8. Acknowledgements
9. References
10. Entire manuscript

Key words: Bone, ERK, SAPK, JNK, p38, Elk-1, fos, jun, AP-1