[Frontiers in Bioscience 3, d838-848, August 1, 1998]
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CAVEAT LECTOR




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TRANSCRIPTIONAL COACTIVATORS POTENTIATING AP-1 FUNCTION IN BONE

René St-Arnaud and Isabelle Quélo

Genetics Unit, Shriners Hospital, and Departments of Surgery and Human Genetics, McGill University, Montréal (Québec) Canada H3G 1A6

Received 3/27/98 Accepted 4/22/98

TABLE OF CONTENTS

1. Abstract
2.Introduction
2.1. bone development and the cells of bone
2.2. AP-1 and bone development
3. AP-1
3.1. the fos family
3.2. the jun family
3.3. the AP-1 binding site
3.4. post-translational modulation of AP-1 function
4. Coactivators potentiating AP-1 activity
4.1. CBP
4.2. JAB1
4.3. alpha-NAC
5. Perspectives
6. Acknowledgements
7. References
8. Entire manuscript

Key words: Coactivator, Transcription, AP-1, Bone development