[Frontiers in Bioscience 3, d865-876, August 5, 1998]
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INTERACTION OF MYCOBACTERIAL GLYCOLIPIDS WITH HOST CELLS

Isabelle Vergne and Mamadou Daffé

Institut de Pharmacologie et Biologie Structurale du Centre National de la Recherche Scientifique, 205 route de Narbonne, 31077 Toulouse Cedex France

Received 7/23/98 Accepted 7/25/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Structure, distribution and localization of mycobacterial glycolipids
3.1. Acylated trehaloses
3.1.1. Trehalose dimycolate
3.1.2. Sulfatides
3.1.3. Miscellaneous trehalose esters
3.2. Lipooligosaccharides
3.3. Mycosides
3.3.1. Glycopeptidolipids
3.3.2. Phenolic glycolipids
3.4. Phosphatidylinositolmannosides
4. Modulation of host cell response by mycobacterial glycolipids
4.1. Inhibition of macrophage antimicrobial activities
4.1.1. Sulfatides
4.1.2. Phenolic glycolipids
4.1.3. Glycopeptidolipids
4.2. Inhibition of lymphoproliferation
4.2.1. Phenolic glycolipids
4.2.2. Glycopeptidolipids
4.2.3. Phospholipids
5. Interaction of mycobacterial glycolipids with biologic membranes
5.1. Trehalose dimycolate
5.2. Glycopeptidolipids
5.3. Phosphatidylinositolmannosides
6. Conclusions and perspectives
7. References
8. Entire manuscript

Key words: Mycobacteria, Glycolipids, Membranes, Macrophages