[Frontiers in Bioscience 3, d934-943, August 6, 1998]
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HORMONAL CONTROL OF PITUITARY PROLACTIN-SECRETING TUMORS

Dipak K. Sarkar, Shane T. Hentges, Alok De and Raghaba H.R. Reddy

Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University, Pullman, WA 99163-6540

Received 7/5/98 Accepted 7/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Physiology of pituitary prolactin
3.1. Physiology of pituitary prolactin
3.2. Prolcatinomas in humans and animals
3.3. Estrogen actions on prolactinomas
3.4. Alcohol, estrogen and prolactinomas
3.5. Xenoestrogens and prolactinomas
3.6. Estrogen regulation of prolactinomas
3.6.1. Estrogen receptors
3.6.2. Estrogen action on protooncogenes
3.6.3. Estrogen action on cell transformation
3.6.4. Factors involved in estrogen-induced tumorigenesis
3.6.4.1. Role of transforming growth factor-alpha
3.6.4.2. Role of insulin-like growth factor -1
3.6.4.3. Role of basic fibroblast growth factor
3.6.4.4. Role of interleukins
3.6.4.5. Role of nerve growth factor
3.6.4.6. Role of transforming growth factor-beta
4. Perspective
5. Acknowledgments
6. References
9. Entire manuscript

Key words: Hormonal Carcinogenesis, Neuroendocrinology, Endocrinology, Pituitary Gland, Lactotropes, Prolactin, Estrogen, Prolactinomas, Human, Animals, Estrogen Receptors, Estrogen-Responsive Genes, Growth Factors, Oncogenes, Alcoholism, Cell Transformation, Cell Proliferation