[Frontiers in Bioscience 3, d1262-1273, December 15, 1998]
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CAVEAT LECTOR




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ROLE OF PP2A IN INTRACELLULAR SIGNAL TRANSDUCTION PATHWAYS

Axel H. Schönthal

Department of Molecular Microbiology and Immunology, K. Norris Jr. Comprehensive Cancer Center, University of Southern California, 2011 Zonal Ave., HMR-405, Los Angeles, CA 90033

Received 8/25/98 Accepted 12/2/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Natural product inhibitors of phosphatases
4. Signal transduction pathways affected by okadaic acid
5. PP2A as a tumor suppressor
6. Experimentally increased PP2A activity
7. Interaction of PP2A with other regulatory proteins
8. Conclusions
9. References
10. Entire manuscript

Key words: Phosphatases; PP2A, Phosphatase Inhibitors, Okadaic Acid, Signal Transduction