[Frontiers in Bioscience, 3, c1-7, March 1, 1998]

	[Frontiers in Bioscience, 3, c1-7, March 1, 1998] Reprints PubMed CAVEAT LECTOR
	A REGULATORY SYSTEM FOR TARGET GENE EXPRESSION Mark M. Burcin, Bert W. O´Malley and Sophia Y. Tsai Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Received 1/17/98 Accepted 2/20/98 5. REFERENCES 1. Zawel L. & D. Reinberg. Initiation of transcription by RNA polymerase II: a multi-step process. Prog Res Mol Biol 44, 67-108 (1993). 2. Tsai M.J. & B.W. O'Malley. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Ann Rev Biochem63, 451-86 (1994). 3. Wang Y., B.W. O'Malley, Jr. S.Y. Tsai & B.W. O'Malley. A regulatory system for use in gene transfer. Proc Natl Acad Sci USA91, 8180-4 (1994). 4. Wang Y., J. Xu, T. Pierson, B.W. O'Malley, & S.Y. Tsai. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Therapy 4, 432-41 (1997). 5. Wang Y., F.J. DeMayo, S.Y. Tsai & B.W. O'Malley: Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotech15, 239-43 (1997). 6. Shockett P.E. & D.G. Schatz: Diverse strategies for tetracycline-regulated inducible gene expression [see comments]. Proc Natl Acad Sci USA93, 5173-6 (1996). 7. Crabtree G.R. & S.L. Schreiber: Three-part inventions: intracellular signaling and induced proximity. Trends Biochem Sci21, 418-22 (1996). 8. Yarranton G.T.: Inducible vectors for expression in mammalian cells. Curr Opin Biotech3, 506-11 (1992). 9. Gossen M., A.L. Bonin & H. Bujard: Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci18, 471-5 (1993). 10. Deuschle, U: Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. Proc Natl Acad Sci USA86, 5400-4 (1989). 11. Baim S.B., M.A. Labow, A.J. Levine & T.A. Shenk: chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside. Proc Natl Acad Sci USA88, 5072-6 (1991). 12. Gossen Ml: Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-9 (1995). 13. Fruh K: A viral inhibitor of peptide transporters for antigen presentation. Nature 375, 415-8 (1995). 14. Gossen M. & H. Bujard: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA89, 5547-51 (1992). 15. Shockett P.,V. Difilippantonio, N. Hellman & D.G. Schatz: A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA92, 6522-6 (1995). 16. Rivera V.M.: A humanized system for pharmacologic control of gene expression [see comments]. Nature Med 2, 1028-32 (1996). 17. No D., T.P. Yao & R.M. Evans: Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci USA 93, 3346-51 (1996). 18. Braselmann S., P. Graninger & M. Busslinger: A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci USA90, 1657-61 (1993). 19. Wegner M., D.W. Drolet & M.G. Rosenfeld: POU-domain proteins: structure and function of developmental regulators. Curt Opin Cell Biol 5, 488-98 (1993). 20. Gerber H.P.: Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263, 808-11 (1994). 21. Yan C., R.H. Costa, J.E. Darnell Jr., J.D. Chen & T.A.Van Dyke: Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J 9, 869-78 (1990). 22. Wu H.: Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev 10, 245-60 (1996). 23. Witzgall R., E. O'Leary, R. Gessner, A.J. Ouellette & J.V. Bonventre: Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol Cell Biol 13, 1933-42 (1993). 24. Witzgall R., E. O'Leary, A. Leaf, D. Onaldi & J.V. Bonventre: The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci USA91, 4514-8 (1994). 25. Margolin J.F.: Kruppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci USA91, 4509-13 (1994). 26. Silvestris F.: [Apoptosis or programmed cell death: regulatory and pathophysiological mechanisms (editorial)]. Annali Italiani di Medicina Interna 10, 7-13 (1995). 27. Vito P., E. Lacana & L. D'Adamio: Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271, 521-5 (1996). 28. Anderson A.J., C.J. Pike & C.W. Cotman: Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. J Neurochem 65, 1487-98 (1995). 29. Onate S.A., S.Y. Tsai, M.J. Tsai & B.W. O'Malley: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-7 (1995). 30. Eckner R.: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev 8, 869-84 (1994). 31. Schmitz M.L. & P.A. Baeuerle: The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO Journal 10, 3805-17 (1991). 32. Muller W.J.: The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J 9, 907-13 (1990). 33. Hanahan D.: Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-22 (1985). 34. Phi-Van L., J.P. von Kries, W. Ostertag & W.H. Stratling: The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol Cell Biol 10, 2302-7 (1990). 35. Chung J.H., M. Whiteley & G. Felsenfeld: A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74, 505-14 (1993). 36. Kochanek S.: A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA93, 5731-6 (1996). 37. Lakso M.: Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA89, 6232-6 (1992). 38. Orban P.C., D. Chui & J.D. Marth: Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA89, 6861-55 (1992). 39. Gu H., J.D. Marth, P.C. Orban, H. Mossmann & K. Rajewsky: Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting [see comments]. Science 265, 103-6 (1994)

[Frontiers in Bioscience, 3, c1-7, March 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

A REGULATORY SYSTEM FOR TARGET GENE EXPRESSION

Mark M. Burcin, Bert W. O´Malley and Sophia Y. Tsai

Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Received 1/17/98 Accepted 2/20/98

5. REFERENCES

1. Zawel L. & D. Reinberg. Initiation of transcription by RNA polymerase II: a multi-step process. Prog Res Mol Biol 44, 67-108 (1993).

2. Tsai M.J. & B.W. O'Malley. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Ann Rev Biochem63, 451-86 (1994).

3. Wang Y., B.W. O'Malley, Jr. S.Y. Tsai & B.W. O'Malley. A regulatory system for use in gene transfer. Proc Natl Acad Sci USA91, 8180-4 (1994).

4. Wang Y., J. Xu, T. Pierson, B.W. O'Malley, & S.Y. Tsai. Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Therapy 4, 432-41 (1997).

5. Wang Y., F.J. DeMayo, S.Y. Tsai & B.W. O'Malley: Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotech15, 239-43 (1997).

6. Shockett P.E. & D.G. Schatz: Diverse strategies for tetracycline-regulated inducible gene expression [see comments]. Proc Natl Acad Sci USA93, 5173-6 (1996).

7. Crabtree G.R. & S.L. Schreiber: Three-part inventions: intracellular signaling and induced proximity. Trends Biochem Sci21, 418-22 (1996).

8. Yarranton G.T.: Inducible vectors for expression in mammalian cells. Curr Opin Biotech3, 506-11 (1992).

9. Gossen M., A.L. Bonin & H. Bujard: Control of gene activity in higher eukaryotic cells by prokaryotic regulatory elements. Trends Biochem Sci18, 471-5 (1993).

10. Deuschle, U: Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. Proc Natl Acad Sci USA86, 5400-4 (1989).

11. Baim S.B., M.A. Labow, A.J. Levine & T.A. Shenk: chimeric mammalian transactivator based on the lac repressor that is regulated by temperature and isopropyl beta-D-thiogalactopyranoside. Proc Natl Acad Sci USA88, 5072-6 (1991).

12. Gossen Ml: Transcriptional activation by tetracyclines in mammalian cells. Science 268, 1766-9 (1995).

13. Fruh K: A viral inhibitor of peptide transporters for antigen presentation. Nature 375, 415-8 (1995).

14. Gossen M. & H. Bujard: Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA89, 5547-51 (1992).

15. Shockett P.,V. Difilippantonio, N. Hellman & D.G. Schatz: A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice. Proc Natl Acad Sci USA92, 6522-6 (1995).

16. Rivera V.M.: A humanized system for pharmacologic control of gene expression [see comments]. Nature Med 2, 1028-32 (1996).

17. No D., T.P. Yao & R.M. Evans: Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci USA 93, 3346-51 (1996).

18. Braselmann S., P. Graninger & M. Busslinger: A selective transcriptional induction system for mammalian cells based on Gal4-estrogen receptor fusion proteins. Proc Natl Acad Sci USA90, 1657-61 (1993).

19. Wegner M., D.W. Drolet & M.G. Rosenfeld: POU-domain proteins: structure and function of developmental regulators. Curt Opin Cell Biol 5, 488-98 (1993).

20. Gerber H.P.: Transcriptional activation modulated by homopolymeric glutamine and proline stretches. Science 263, 808-11 (1994).

21. Yan C., R.H. Costa, J.E. Darnell Jr., J.D. Chen & T.A.Van Dyke: Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice. EMBO J 9, 869-78 (1990).

22. Wu H.: Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev 10, 245-60 (1996).

23. Witzgall R., E. O'Leary, R. Gessner, A.J. Ouellette & J.V. Bonventre: Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Mol Cell Biol 13, 1933-42 (1993).

24. Witzgall R., E. O'Leary, A. Leaf, D. Onaldi & J.V. Bonventre: The Kruppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci USA91, 4514-8 (1994).

25. Margolin J.F.: Kruppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci USA91, 4509-13 (1994).

26. Silvestris F.: [Apoptosis or programmed cell death: regulatory and pathophysiological mechanisms (editorial)]. Annali Italiani di Medicina Interna 10, 7-13 (1995).

27. Vito P., E. Lacana & L. D'Adamio: Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science 271, 521-5 (1996).

28. Anderson A.J., C.J. Pike & C.W. Cotman: Differential induction of immediate early gene proteins in cultured neurons by beta-amyloid (A beta): association of c-Jun with A beta-induced apoptosis. J Neurochem 65, 1487-98 (1995).

29. Onate S.A., S.Y. Tsai, M.J. Tsai & B.W. O'Malley: Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 270, 1354-7 (1995).

30. Eckner R.: Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev 8, 869-84 (1994).

31. Schmitz M.L. & P.A. Baeuerle: The p65 subunit is responsible for the strong transcription activating potential of NF-kappa B. EMBO Journal 10, 3805-17 (1991).

32. Muller W.J.: The int-2 gene product acts as an epithelial growth factor in transgenic mice. EMBO J 9, 907-13 (1990).

33. Hanahan D.: Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315, 115-22 (1985).

34. Phi-Van L., J.P. von Kries, W. Ostertag & W.H. Stratling: The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol Cell Biol 10, 2302-7 (1990).

35. Chung J.H., M. Whiteley & G. Felsenfeld: A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 74, 505-14 (1993).

36. Kochanek S.: A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Natl Acad Sci USA93, 5731-6 (1996).

37. Lakso M.: Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA89, 6232-6 (1992).

38. Orban P.C., D. Chui & J.D. Marth: Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA89, 6861-55 (1992).

39. Gu H., J.D. Marth, P.C. Orban, H. Mossmann & K. Rajewsky: Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting [see comments]. Science 265, 103-6 (1994)