[Frontiers in Bioscience, 3, c1-7, March 1, 1998]
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A REGULATORY SYSTEM FOR TARGET GENE EXPRESSION

Mark M. Burcin, Bert W. OŽMalley and Sophia Y. Tsai

Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Received 1/17/98 Accepted 2/20/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Regulatory Systems for target gene expression
3.1. ITPG based regulatory systems
3.2. Tetracyclin based regulatory systems
3.3. CID based regulatory system
3.4. Ecdysone based regulatory system
3.5. Estrogen-based regulatory system
3.6. A novel regulatory system based on a mutated progesterone receptor ligand binding domain.
3.6.1. Modifications of GLVP
3.6.2. Creation of ligand inducible target genes in transgenic mice
3.6.3. Inducible gene repression
3.6.4. Future applications for the regulatory system
4. Acknowledgments
5. References
6. Entire manuscript

Key words: Inducible system, Gene therapy, Transgenic mice, Gene activation, Repression, RU486