[Frontiers in Bioscience 3, c27-33, May 1, 1998]
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LURIE’S TUBERCLE-COUNT METHOD TO TEST TB VACCINE EFFICACY IN RABBITS

Arthur M. Dannenberg, Jr.

Departments of Environmental Health Sciences, Molecular Microbiology and Immunology, and Epidemiology, School of Hygiene and Public Health; and the Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

Received 3/9/98 Accepted 3/14/98

12. SUMMARY

We urge TB investigators to use Lurie’s tubercle count method to assess the efficacy of TB vaccines in preventing progressive tuberculosis in laboratory animals. The method provides information directly applicable to human pulmonary tuberculosis, but it has been largely neglected since 1952. It was originally published for rabbits, and still remains to be used as a standard method for evaluating TB vaccines in guinea pigs and in mice.