[Frontiers in Bioscience 3, c27-33, May 1, 1998]
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CAVEAT LECTOR




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LURIE’S TUBERCLE-COUNT METHOD TO TEST TB VACCINE EFFICACY IN RABBITS

Arthur M. Dannenberg, Jr.

Departments of Environmental Health Sciences, Molecular Microbiology and Immunology, and Epidemiology, School of Hygiene and Public Health; and the Department of Pathology, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205

Received 3/9/98 Accepted 3/14/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Description of the tubercle-count method
4. Resistance to the establishment of the infection
5. Immune mechanisms controlling the progress of the early microscopic pulmonary lesion
6. How vaccines prevent grossly visible TB lesions
7. Effects of vaccines on the 5 stages of tuberculosis
7.1 Stage 1. Destruction of the bacillus by alveolar macrophages
7.2 Stage 2. Symbiosis
7.3 Stage 3. Initial caseous necrosis
7.4 Stage 4. Progression or regression of the established primary tubercle
7.5 Stage 5. Liquefaction and cavity formation
7.6. Relevance
8. Dose effects
9. Single primary TB lesions
10. Tuberculosis in different species
11. Application of the tubercle-count method to guinea pigs and mice
12. Summary
13. Acknowledgments
14. References
15. Entire manuscript

Key words:Tuberculosis, T.B., Vaccine, Tubercle, Rabbit, Guinea pig, Mouse