[Frontiers in Bioscience 3, c17-26, April 16, 1998]
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IN SEARCH OF AN ANIMAL MODEL FOR POSTMENOPAUSAL DISEASES

E. A. Thorndike and A. S. Turner

Department of Clinical Sciences, Colorado State University, Ft.Collins ,CO 80523

Received 9/25/97 Accepted 4/10/98

TABLE OF CONTENTS


1.Abstract
2. General introduction to animal models
3. A brief overview of conditions associated with cessation of ovarian function
4. Coronary artery disease (CAD)
4.1. Animal Models Used to Study CAD
4.2. The Use of Sheep to Study CAD

5. Osteoporosis
5.1 Animal Models to Study Osteoporosis
5.2 Sheep as a Model for Osteoporosis

6.Osteoarthritis (OA)
6.1 The Relationship Between Estrogen and OA
6.2 The Use of Sheep as a Model for OA
6.3 The Relationship between Estrogen and OA in Sheep

7.Oral bone loss
7.1 The Use of Sheep to Study Oral Bone Loss

8.Perspective
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Animal Models, Sheep, Menopause, Coronary Artery Disease, Osteoporosis, Osteoarthritis, Oral Bone Loss, Estrogen