[Frontiers in Bioscience 3, d559-569, June 16, 1998]
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MACROKINES: INVERTEBRATE CYTOKINE-LIKE MOLECULES?

Gregory Beck

Department of Biology, University of Massachusetts at Boston, 100 Morrissey Blvd., Boston, MA 02125-3393 USA

Received 4/3/98 Accepted 6/11/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Invertebrate host defense concepts
3.1. Interleukin 1
3.2. Interleukin 6
3.3. Our Previous Studies of Invertebrate Cytokine-like Molecules
3.4. Cytokine-like Molecules and Receptors in Other Lower Species
3.5. Molecular Evolution Studies of Vertebrate Cytokines and its Possible Relationship to Invertebrate Studies
3.6. Our most recent molecular data
4. Perspective
5. Acknowledgements
6. References
7. Entire manuscript

Key words: Evolution, Immunology, Host Defense, Innate, Coelomocytes, Hemocytes, Interleukin, Invertebrate, Cytokine, IL-1, IL-6

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