[Frontiers in Bioscience 3, d1220-1240, December 1, 1998]
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CAVEAT LECTOR




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VOLTAGE DEPENDENT CALCIUM CHANNELS IN MAMMALIAN SPERMATOZOA

Susan Benoff

Division of Human Reproduction, Department of Obstetrics and Gynecology, North Shore University Hospital-New York University School of Medicine, Manhasset, New York

Received 7/1/98 Accepted 11/10/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Calcium channels in spermatozoa
3.1. Biological findings
3.2. Data gained from molecular cloning
4. Role of L-type VDCC in the acrosome reaction and human male infertility
5. Contraception
6. Susceptibility to environmental toxicants
7. Perspectives
7.1. Conclusions
7.2. T-type calcium currents and VDCC subunit composition
8. Acknowledgments
9. References
10. Entire manuscript

Key words: Testis, Sperm, Calcium Channels, Isoforms, Alternate Splicing, Infertility, Contraception, Environmental Exposures