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[Frontiers in Bioscience 3, d169-175, February 15, 1998] Reprints PubMed CAVEAT LECTOR |
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FREE FATTY ACIDS (FFA), A LINK BETWEEN OBESITY AND INSULIN RESISTANCE Division of Endocrinology/Diabetes/Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA Received 1/21/98 Accepted 1/31/98 8. REFERENCES 1. Zavaroni I, E. Bonora, M. Paliara, E. Dall=Aglio, L. Luchetti, G. Buonanno, P.A. Bonati, M. Bergonazani, L. Gnudi, M. Passeri & G. Reaven: Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320:702-706 (1989) 2. Fontbonne A.M. & E.M. Eschwege:. Insulin and cardiovascular disease. Paris prospective study. Diabetes Care 14:461-469 (1991) 3. Sims E.A.H., E. Danforth Jr, E.S. Horton, G.A. Bray, J.A.Glennon & L.B. Salans: Endocrine and metabolic effects of experimental obesity in man. Rec Prog Horm Res 29:457-496 (1973) 4. Goto Y, Y. Nakayama & T. Yagi: Influence of the World War II food shortage on the incidence of diabetes mellitus in Japan. Diabetes 7:133-135 (1958) 5. Schliack V: Mangelernahrung und Diabetes Morbiditat. Z Klin Med 151:382-396 (1954) 6. Pascoe W.S. & L.H. Storlien: Inducement by fat feeding of basal hyperglycemia in rats with abnormal beta-cell function. Model for study of etiology and pathogenesis of NIDDM. Diabetes 39:226-233 (1990) 7. Gorden E.S.: Non-esterified fatty acids in blood of obese and lean subjects. Am J Clin Nutr 8:740-747 (1960) 8. Reaven G.M., C. Hollenbeck, C-Y Jeng, M.S. Wu & Y-DChen: Measurement of plasma glucose, free fatty acid, lactate and insulin for 24 h in patients with NIDDM. Diabetes 37:1020-1024 (1988) 9. Bjorntorp P, H. Bergman & E. Varnauskas: Plasma free fatty acid turnover in obesity. Acta Med Scand 185:351-356 (1969) 10. Jensen M.D., M.W. Haymond, R.A Rizza, P.E. Cryer & J.M. Miles: Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 83:1168-1173 (1989) 11. DeFronzo R.A., J.D. Tobin & R. Andres: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 6:E214-E223 (1979) 12. Boden G & F. Jadali: Effects of lipid on basal carbohydrate metabolism in normal men. Diabetes 40:686-692 (1991) 13. Boden G, F. Jadali, J. White, Y. Liang, M. Mozzoli, X. Chen, E. Coleman & C. Smith: Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88:960-966 (1991) 14. Boden G, X. Chen, J. Ruiz, J.V. White & L. Rossetti: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446 (1994) 15. Boden G & X. Chen: Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96:1261-1268 (1995) 16. Roden M, T.B. Price, G. Perseghin, K.F. Petersen, D.L. Rothman, G.W. Cline & G.I. Shulman: Mechanisms of free fatty acid induced insulin resistance in humans. J Clin Invest 17:2859-2865 (1996) 17. Thiebaud D, R. A. DeFronzo, E. Jacot, A. Golay, K. Acheson, E. Maeder, E. Jequier, J-P Felber: Effect of long chain triglyceride infusion on glucose metabolism in man. Metab Clin Exp 31:1128-1136 (1982) 18. Felley CP, E.M. Felley, G.D. van Melle, P. Frascarolo, E. Jequier & J.P. Felber: Impairment of glucose disposal by infusion of triglycerides in humans: role of glycemia. Am J Physiol 256:E747-E752 (1989) 19. Lee HU, H.K. Lee, C.S Koh & H.K Min: Artificial induction of intravascular lipolysis by lipid-heparin infusions leads to insulin resistance in man. Diabetologia 31:285-290 (1988) 20. Bonadonna RC, K. Zych, C. Boni, E. Ferrannini & R.A. DeFronzo: Time dependence of the interaction between lipid and glucose in humans. Am J Physiol 257:E49-E56 (1989) 21. Wolfe B, M.S. Klein, E.J. Peters, B.F. Schmidt & R.R. Wolfe: Effect of elevated free fatty acids on glucose oxidation in normal humans. Metab Clin Exp 37:323-329 (1988) 22. Bevilacqua S, R. Bonadonna, G. Buzzigoli, C. Boni, D. Ciociaro, F. Maccari, M.A. Giorico & E. Ferrannini: Acute elevation of free fatty acid levels leads to hepatic insulin resistance in obese subjects. Metab Clin Exp 36:502-506 (1987) 23. Bevilacqua S, G. Buzzigoli, R. Bonadonna, S. Brandi, M. Oleggini, C. Boni, M. Geloni & E. Ferrannini: Operation of Randle=s cycle in patients with NIDDM. Diabetes 39:383-389 (1990) 24. Yki-Jarvinen H, H.I. Puhakainen, C. Saloranta, L. Groop & M-R Taskinen: Demonstration of a novel feedback mechanism between FFA oxidation from intracellular and intravascular sources. Am J Physiol 260:E680-E689 (1991) 25. Saloranta C, A. Franssila-Kallunki, A. Ekstrand, M-R Taskinen & L. Groop: Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:409-415 (1991) 26. Rossetti L, Y.T. Lee, J. Ruiz, S.C. Aldridge, H. Shamoon & G. Boden: Quantitation of glycolysis and skeletal muscle glycogen synthesis in humans. Am J Physiol 265:E761-E769 (1993) 27. Randle P.J., P.B. Garland, C.N. Hales & E.A. Newsholme: The glucose fatty-acid cycle; its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i:785-789 (1963) 28. Kelley D.E., M. Mokan, J-A Simoneau & L.J. Mandarino: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92:91-98 (1993) 29. Marshall S, V. Bacote & R.R. Traxinger: Discovery of a metabolic pathway mediating glucose-induced desensitization of glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance. J Biol Chem 266:4706-4712 (1991) 30. Traxinger R.R. & S. Marshall: Recovery of maximal insulin responsiveness and insulin sensitivity after induction of insulin resistance in primary cultured adipocytes. J Biol Chem 264:8156-8163 (1989) 31. Hawkins M, I. Angelov, R. Liu, N. Barzilai & L. Rossetti: The tissue concentration of UDP-N-acetylglucosamine modulates the stimulatory effect of insulin on skeletal muscle glucose uptake. J Biol Chem 272:4889-4895 (1997) 32. Hawkins M, N. Barzilai, R. Liu, M. Hu, W. Chen & L. Rossetti: Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 99:2173-2182 (1997) 33 Long S.D. & P.H. Pekala: Regulation of Glut4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2. J Biol Chem 271:1138-1144 (1996) 34. Ginsberg B.H., T.J. Brown, I. Simon & A. A. Spector: Effect of membrane lipid environment on the properties of insulin receptors. Diabetes 30:773-780 (1981) 35. Grunfeld C, K.L. Baird & C.R. Kahn: Maintenance of 3T3-L1 cells in cultured media containing saturated fatty acids decreases insulin binding and insulin action. Biochem Biophys Res Commun 103:219-226 (1981) 36. Farias R.N.: Insulin-membrane interactions and membrane fluidity changes. Biochem Biophys Acta 906:459-468 (1987) 37. Borkman M, L.H. Storlien, D.A. Pan, A.B. Jenkins, D.J. Chisholm & L.V. Campbell: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med 328:238-244 (1993) 38. Ferrannini E, E. Barrett, S. Bevilacqua & R. DeFronzo: Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747 (1983) 39. Fanelli C, S. Calderone, L. Epifano, A. DeVincenzo, F. Modarelli, S. Pampanelli, G. Perriello, P. DeFeo, P. Brunetti, J.E. Gerich & G.B. Bolli: Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans. J Clin Invest 92:1617-1622 (1993) 40. Saloranta C, V. Koivisto, E. Widen, K. Falholt, R. DeFronzo, M. Harkonen & L. Groop: Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol 264:E599-E605 (1993) 41. Rebrin K, G.M. Steil, L. Getty & R.N. Bergman: Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44:1038-1045 (1995) 42. Fulcher G.R., M. Walker, C. Catalano, L. Aquis & K.G.M.M Alberti: Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects. Diabetes 41:1400-1408 (1992) 43. Worm D, J.E. Henriksen, A. Vaag, P. Thye-Ronn, A. Melander & H. Beck-Nielsen: Pronounced blood glucose-lowering effect of the antilipolytic drug acipimox in noninsulin-dependent diabetes mellitus patients during a 3-day intensified treatment period. J Clin Endocrinol Metab 78:717-721 (1994) 44. Vaag A, P. Skott, P. Damsbo, M-A Gall, E.A. Richter & H. Beck-Nielsen: Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with noninsulin-dependent diabetes mellitus. J Clin Invest 88:1282-1290 (1991) 45. Puhakainen I & H. Yki-Jarvinen: Inhibition of lipolysis decreases lipid oxidation and gluconeogenesis from lactate but not fasting hyperglycemia or total hepatic glucose production in NIDDM. Diabetes 42:1694-1699 (1993) 46. Williamsson J.R., R.A. Kreisberg & P.W. Felts: Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver. Proc Natl Acad Sci USA 6:247-254 (1966) 47. Gonzalez-Manchon C, M.S. Ayuso & R. Parrilla: Control of hepatic gluconeogenesis: role of fatty acid oxidation. Arch Biochem Biophys 271:1-9 (1989) 48. Morand C, C. Remesy & C. Demigne: Fatty acids are potent modulators of lactate utilization in isolated hepatocytes from fed rats. Am J Physiol 264:E816-E823 (1993) 49. Jomain-Baum M & R.W. Hanson: Regulation of hepatic gluconeogenesis in the guinea pig by fatty acids and ammonia. J Biol Chem 250:8978-8985 (1975) 50. Williamson J, E. Browning & R. Scholz: Control mechanisms of gluconeogenesis and ketogenesis. J Biol Chem 224:4607-4616 (1969) 51. Clore J.N., P.S. Glickman, S.T. Helm, J.E. Nestler & W.G. Blackard: Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men. Diabetes 40:1033-1040 (1991) 52. Metzger B.E., V. Ravnikar, R.A Vileisis & N. Freinkel: "Accelerated starvation" and the skipped breakfast in late normal pregnancy. Lancet 1:588-592 (1982) 53. Boden G: Fuel metabolism in pregnancy and in gestational diabetes mellitus. Obstet and Gynecol Clinics of North America 23:1-10 (1996) 54. Reaven GM: Role of insulin resistance in human disease. Diabetes 37:1595-1607 (1988) Footnote: *: These figures were reproduced with permission from the American Society for Clinical Investigation |