{Frontiers in Bioscience, 3, d637-649, July 1, 1998]
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CD44 ISOFORM-CYTOSKELETON INTERACTION IN ONCOGENIC SIGNALING AND TUMOR PROGRESSION

Lilly Y.W. Bourguignon, Dan Zhu and Hongbo Zhu

Department of Cell Biology and Anatomy, University of Miami Medical School, Miami, Fl. 33101

Received 54/27/98 Accepted 5/15/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Biosynthetic pathways and posttranslational modifications of CD44 isoforms
3.1. CD44s (the standard form)
3.2. CD44v (variant isoforms)
4. Transmembrane interaction between CD44 isoforms and the cytoskeleton
4.1. CD44 isoforms and ankyrin
4.2. CD44 isoforms and ERM (ezrin, radixin, moesin and merlin)
5. CD44s interaction with signaling molecules in oncogenesis
5.1. CD44s and the oncogene product, p185HER2
5.2. CD44s and Src Kinases
6. CD44v isoforms and tumor progression
6.1. CD44v10 isoform in tumor cell growth
6.2. CD44v3 isoforms in tumor cell invasion and migration
7. Perspective
8. Acknowledgements
9. References
10. Entire manuscript

Key words: CD44s, Ankyrin Binding, Hyaluronic Acid (HA), Cell Adhesion, p185HER2, Src Kinases, Metalloproteinases (MMPs), Tumor Cell Growth, Tumor Metastasis

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