[Frontiers in Bioscience 3, d113-124, January 15, 1998]
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CONTROL OF TGF-BETA RECEPTOR EXPRESSION IN BONE

Michael Centrella, Changhua Ji, Thomas L. McCarthy

Department of Surgery, Plastic Surgery Section, Yale University School of Medicine, 333 Cedar Street, PO Box 208041, New Haven, CT 06520-8041,

Received 12/1/97 Accepted 12/5/97

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Bone growth and remodeling
4. Bone growth regulators
5. TGF-beta supergene family and bone
6. TGF-beta receptors
7. Effects of TGF-beta on bone cell activity
8. Regulation of TGF-beta receptors on bone cells
9. TGF-beta receptor I promoter
10. Nuclear factor CBFa
11. CBFa, TGF-beta receptor I, and bone
12. Perspective
13. Acknowledgment
14. References
15. Entire manuscript

Key words: Biochemistry and molecular biology, bone, osteoblasts, TGF-beta receptors, Cloning, sequencing, gel shift, RNA and protein analyses

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