[Frontiers in Bioscience 3, d997-1004, September 15, 1998]

	[Frontiers in Bioscience 3, d997-1004, September 15, 1998] Reprints PubMed CAVEAT LECTOR
	SYSTEMIC GENE THERAPY WITH P53 INHIBITS BREAST CANCER: RECENT ADVANCES AND THERAPEUTIC IMPLICATIONS Qing-Rong Chen and A. James Mixson University of Maryland Baltimore, Room 759, Bldg MSTF, 10 South Pine Street, Baltimore MD 21201 Received 8/13/98 Accepted 8/17/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 2.1. Vectors: advantages and limitations 2.2. Incidence of p53 mutations in breast cancer 2.3. p53 regulates a number of cellular functions 3. The tumor suppressor gene, p53, inhibits tumor growth in vivo 3.1. Intratumoral administration 3.2. Regional intravenous administration 3.3. Systemic intravenous administration of liposome: p53 complexes 3.3.1. Inhibition but also regression with p53 3.3.2. Effects of gene therapy with p53 are independent of p53 status of tumor 3.3.3. Toxicity of the liposome: p53 complex 4. Mechanism of inhibition 5. Gene therapy with genes encoding antiangiogenic peptides/ polypeptides inhibits tumor growth 6. Non-specific antitumor effects 7. Perspective 8. Acknowledgment 9. References 10. Entire manuscript Key words: p53, Liposome, Angiogenesis, Thrombospondin I, Gene therapy Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d997-1004, September 15, 1998]
Reprints
PubMed
CAVEAT LECTOR

SYSTEMIC GENE THERAPY WITH P53 INHIBITS BREAST CANCER: RECENT ADVANCES AND THERAPEUTIC IMPLICATIONS

Qing-Rong Chen and A. James Mixson

University of Maryland Baltimore, Room 759, Bldg MSTF, 10 South Pine Street, Baltimore MD 21201

Received 8/13/98 Accepted 8/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. Vectors: advantages and limitations
2.2. Incidence of p53 mutations in breast cancer
2.3. p53 regulates a number of cellular functions
3. The tumor suppressor gene, p53, inhibits tumor growth in vivo
3.1. Intratumoral administration
3.2. Regional intravenous administration
3.3. Systemic intravenous administration of liposome: p53 complexes

3.3.1. Inhibition but also regression with p53
3.3.2. Effects of gene therapy with p53 are independent of p53 status of tumor
3.3.3. Toxicity of the liposome: p53 complex

4. Mechanism of inhibition

5. Gene therapy with genes encoding antiangiogenic peptides/ polypeptides inhibits tumor growth

6. Non-specific antitumor effects

7. Perspective

8. Acknowledgment

9. References

10. Entire manuscript

Key words: p53, Liposome, Angiogenesis, Thrombospondin I, Gene therapy

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.