[Frontiers in Bioscience 3, d997-1004, September 15, 1998]
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CAVEAT LECTOR




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SYSTEMIC GENE THERAPY WITH P53 INHIBITS BREAST CANCER: RECENT ADVANCES AND THERAPEUTIC IMPLICATIONS

Qing-Rong Chen and A. James Mixson

University of Maryland Baltimore, Room 759, Bldg MSTF, 10 South Pine Street, Baltimore MD 21201

Received 8/13/98 Accepted 8/17/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
2.1. Vectors: advantages and limitations
2.2. Incidence of p53 mutations in breast cancer
2.3. p53 regulates a number of cellular functions
3. The tumor suppressor gene, p53, inhibits tumor growth in vivo
3.1. Intratumoral administration
3.2. Regional intravenous administration
3.3. Systemic intravenous administration of liposome: p53 complexes
3.3.1. Inhibition but also regression with p53
3.3.2. Effects of gene therapy with p53 are independent of p53 status of tumor
3.3.3. Toxicity
of the liposome: p53 complex
4. Mechanism of inhibition
5. Gene therapy with genes encoding antiangiogenic peptides/ polypeptides inhibits tumor growth
6. Non-specific antitumor effects
7. Perspective
8. Acknowledgment
9. References
10. Entire manuscript

Key words: p53, Liposome, Angiogenesis, Thrombospondin I, Gene therapy

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