Richard J. Cristiano

Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 109, Houston, Texas 77030

Received 7/21/98 Accepted 7/25/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Cell-Specific Targeting Ligands
4. Endosomal Lysis Agents; Viruses vs. Peptides vs. Polycations
5. DNA-binding Agents
6. Nucleic Acids and In vitro/In Vivo Applications
7. Molecular Conjugates vs. Other Delivery Systems
8. Future Directions
9. Acknowledgments
10. References
11. Entire manuscript

Key words: Protein/DNA polyplex; gene therapy; ligand; receptor-mediated endocytosis: non-viral

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