[Frontiers in Bioscience 3, d25-43, January 1, 1998]

	[Frontiers in Bioscience 3, d25-43, January 1, 1998] Reprints PubMed CAVEAT LECTOR
	HOW DO INTRACELLULAR PROTEOLYTIC SYSTEMS CHANGE WITH AGE? Ana Maria Cuervo and J. Fred Dice Department of Physiology Tufts University School of Medicine, Boston, USA Received 12/5/97 Accepted 12/9/97 TABLE OF CONTENTS 1. Abstract 2. Introduction: what happens to senescent cells? 3. Model systems for the study of aging 4. Intracellular proteolytic systems and aging 4.1. Cytosolic proteolytic systems: Proteasomes and calpains 4.1.1. Ubiquitin-proteasome system 4.1.2. Calpains 4.2. Lysosomal proteolytic pathways 4.2.1. Fusion of lysosomes with vesicular compartments 4.2.2. Macroautophagy and microautophagy 4.2.3. Direct transport of cytosolic proteins through the lysosomal membrane 5. Tissue-specific changes in proteolytic systems with aging 5.1. Central nervous system 5.2. Liver and cultured fibroblasts 5.3. Skeletal muscle 5.4. Eye lens 6. Conclusions and perspectives 7. Acknowledgments 8. References 9. Entire manuscript Key words: Aging; Proteases, Molecular chaperones; Proteasome, Lysosomes, Calpains Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d25-43, January 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

HOW DO INTRACELLULAR PROTEOLYTIC SYSTEMS CHANGE WITH AGE?

Ana Maria Cuervo and J. Fred Dice

Department of Physiology Tufts University School of Medicine, Boston, USA

Received 12/5/97 Accepted 12/9/97

TABLE OF CONTENTS

1. Abstract
2. Introduction: what happens to senescent cells?
3. Model systems for the study of aging
4. Intracellular proteolytic systems and aging: 4.1. Cytosolic proteolytic systems: Proteasomes and calpains
4.1.1. Ubiquitin-proteasome system
4.1.2. Calpains
4.2. Lysosomal proteolytic pathways
4.2.1. Fusion of lysosomes with vesicular compartments
4.2.2. Macroautophagy and microautophagy
4.2.3. Direct transport of cytosolic proteins through the lysosomal membrane
5. Tissue-specific changes in proteolytic systems with aging: 5.1. Central nervous system
5.2. Liver and cultured fibroblasts
5.3. Skeletal muscle
5.4. Eye lens
6. Conclusions and perspectives
7. Acknowledgments
8. References
9. Entire manuscript

Key words: Aging; Proteases, Molecular chaperones; Proteasome, Lysosomes, Calpains

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.