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[Frontiers in Bioscience 3, d1241-1252, December 1, 1998] Reprints PubMed CAVEAT LECTOR |
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INHIBITION OF INTERNAL ENTRY SITE (IRES)-MEDIATED TRANSLATION BY A SMALL YEAST RNA: A NOVEL STRATEGY TO BLOCK HEPATITIS C VIRUS PROTEIN SYNTHESIS Saumitra Das1, Michael Ott2, Akemi Yamane1, Arun Venkatesan1, Sanjeev Gupta2 and Asim Dasgupta1 Department of Microbiology, Molecular Genetics and Immunolog, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-17471 , 2Department of Medicine, Albert Einstein, College of Medicine of Yeshiva University, Bronx, New York 10461-1602 Received 9/18/98 Accepted 9/23/98 6. ACKNOWLEDGMENTS This work was supported by the grant AI-18272 and AI-38056 from the National Institutes of Health to AD. S.G. was supported by grant DK 46952 and the Irma T. Hirschal Charitable Trust. AY was supported by the Cota Robles Fellowship and AV was a Howard Hughes Medical Institute Medical Student Training fellow and was also supported by the NIH Medical Scientist Training Program grant NRSA/GM08042-15. We thank W. Tsai and other members of the Dasgupta laboratory for their support and E. Berlin for excellent secretarial work. We also thank E. Wimmer, M. Gromeier, F. Lasher and H-Lu for PV/HCV, PV/EMCV viruses. We thank Aleem Siddiqui for the PT7-DC 1-341 HCV bicistronic construct. |