[Frontiers in Bioscience 3, d477-482, May 1, 1998]
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CAVEAT LECTOR




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FOUR VARIETIES OF VOLTAGE-GATED PROTON CHANNELS

Thomas E. DeCoursey

Department of Molecular Biophysics and Physiology, Rush Presbyterian St. Luke's Medical Center, 1653 West Congress Parkway, Chicago, IL 60612

Received 4/23/98 Accepted 4/30/98

TABLE OF CONTENTS

1. Abstract

2. Introduction
3. Features shared by all voltage-gated proton channels
3.1. Voltage-dependent gating
3.2. The voltage dependence of gating is modulated strongly by pHo and pHi
3.3. Block by polyvalent cations
3.4. Extremely high selectivity
3.5. H+ current amplitude increases at lower pH
3.6. Extremely small single-channel conductance
3.7. Are H+ channels really ion channels or something else?
4. Differences among types of H+ channels
4.1. Activation kinetics
4.2. Sigmoidicity of activation time course
4.3. Tail current kinetics
4.4. Tail current components and their voltage- and pH-dependence
4.5. [Ca2+]i dependence of H+ currents
5. Perspective
6. Acknowledgements
7. References
8. Entire manuscript

Key words: Ion Channels, Protons, pH, Channel Modulation, Patch Clamp, Phagocytosis

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